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Metapramine
Systematic (IUPAC) name
(RS)-10,11-dihydro-N,5-dimethyl-5 H-dibenz[b,f]azepin-10-amine
Identifiers
CAS number 21730-16-5
ATC code  ?
PubChem 65700
ChemSpider 59127
Chemical data
Formula C16H18N2
Mol. mass 238.33 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Metapramine (Timaxel) is a tricyclic antidepressant (TCA) which was launched for the treatment of depression in France in 1984. [1] [2] [3] In addition to its efficacy against affective disorders, it also has analgesic effects,[4][5] and may be useful in the treatment of pain.

Metapramine has desipramine-like effects, acting as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin.[6][7][5] Uniquely among the TCAs, it lacks anticholinergic properties.[5][5] Metapramine has also been shown to function as a low affinity NMDA receptor antagonist,[5]

See also

References

  1. ^ "Dictionary of Organic Compounds ... - Google Books". http://books.google.com/books?id=kfhQgpqxiVgC&lpg=PA1&dq=metapramine&as_brr=3&pg=PA13#v=onepage&q=metapramine&f=false.  
  2. ^ "Antidepressants, antipsychotics ... - Google Books". http://books.google.com/books?id=yXD4QA-Y_Z0C&lpg=PA248&dq=metapramine&as_brr=3&pg=PA248#v=onepage&q=metapramine&f=false.  
  3. ^ "Timaxel¤: Martindale: The Complete Drug Reference". http://www.medicinescomplete.com/mc/martindale/2009/999920-n1142-g.htm.  
  4. ^ Michael-Titus A, Costentin J (December 1987). "Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants". Pain 31 (3): 391–400. PMID 2827090.  
  5. ^ a b c d e Fialip J, Marty H, Aumaitre O, et al. (1992). "Antinociceptive activity of metapramine in mice. Relationship with its pharmacokinetic properties". Life Sciences 50 (3): 161–8.  
  6. ^ Dagonneau H, Fonlupt P, Pacheco H (1986). "[Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]" (in French). Comptes Rendus Des Séances De La Société De Biologie Et De Ses Filiales 180 (1): 43–8. PMID 3017518.  
  7. ^ Warter JM, Tranchant C, Marescaux C, Depaulis A, Lannes B, Vergnes M (1990). "Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures". Progress in Neuro-psychopharmacology & Biological Psychiatry 14 (2): 261–70. PMID 2106711.  







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