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Methapyrilene: Wikis


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Systematic (IUPAC) name
N,N-dimethyl-N'-pyridin-2-yl- N'-(2-thienylmethyl)ethane-1,2-diamine
CAS number 91-80-5
ATC code R06AC05
PubChem 4098
Chemical data
Formula C 14H19N3S 
Mol. mass 261.387
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
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Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
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Methapyrilene is a antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action. Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM. All of these products were reformulated in the late 1970s, and methapyrilene is no longer used in most countries because it has been known to cause liver damage which can be potentially serious.

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