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IUPAC name
Other names Methoprene, Altosid, Apex, Diacan, Dianex, Kabat, Minex, Pharorid, Precor, ZR-515
CAS number 40596-69-8
PubChem 5366546
ATCvet code QP53BD01
Molecular formula C19H34O3
Molar mass 310.48 g/mol
Appearance Liquid
Boiling point

100 °C at 0.05 mmHg

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Methoprene is a juvenile hormone (JH) analog which can be used as an insecticide that acts as a growth regulator. Methoprene is essentially nontoxic to humans when ingested or inhaled. It is used in drinking water cisterns to control mosquitoes which spread malaria.[2]

Methoprene does not kill adult insects. Instead, it acts as a growth regulator, mimicking natural juvenile hormone of insects. Juvenile hormone must be absent for a pupa to molt to an adult, so methoprene treated larvae will be unable to successfully change from a pupa to the adult insect. This breaks the biological life cycle of the insect preventing recurring infestation. "Methoprene is used in the production of a number of foods including meat, milk, mushrooms, peanuts, rice and cereals. It also has several uses on domestic animals (pets) for controlling fleas. Methoprene is considered a biochemical pesticide because rather than controlling target pests through direct toxicity, methoprene interferes with an insect’s life cycle and prevents it from reaching maturity or reproducing."[3] Methoprene is used most widely as the mosquito larvicide Altosid, which is an important measure in prevention of West Nile virus.

Methoprene is an amber liquid with a faint fruity odor. Among its common uses is for indoor control of fleas and it is also used to control fire ants.

It is one of two active ingredients (the other being fipronil) in Frontline Plus, a product for dogs and cats that kills fleas, flea eggs, & ticks.

It has been suggested that methoprene is responsible for killing and stunting the growth of lobsters in Narragansett Bay.[4]


  1. ^ Merck Index, 11th Edition, 5906.
  2. ^ "Methoprene". Water Sanitation and Health. World Health Organization. Retrieved 2007-09-08.  
  3. ^ "Insect Growth Regulators: S-Hydroprene (128966), S-Kinoprene (107502), Methoprene (105401), S-Methoprene (105402) Fact Sheet". U.S. Environmental Protection Agency. Retrieved 2007-09-09.  
  4. ^ "Are our lobsters casualties in war on mosquitoes?". Retrieved 2008-07-18.  

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