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Methuselah-like proteins: Wikis


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Methuselah N-terminus
Symbol Methuselah_N
Pfam PF06652
InterPro IPR010596
SCOP 1fjr

The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[1]

Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[2]


  1. ^ Alic N, Partridge L (2007). "Antagonizing Methuselah to extend life span". Genome Biology 8 (8): 222. doi:10.1186/gb-2007-8-8-222. PMID 17764591.  
  2. ^ West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ (March 2001). "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan". Proceedings of the National Academy of Sciences of the United States of America 98 (7): 3744–9. doi:10.1073/pnas.051625298. PMID 11274391.  


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