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Methyl aminolevulinate: Wikis

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Methyl aminolevulinate
Systematic (IUPAC) name
methyl 5-amino-4-oxo-pentanoate
Identifiers
CAS number 33320-16-0
ATC code L01XD03
PubChem 157922
DrugBank APRD01105
Chemical data
Formula C 6H11NO3  
Mol. mass 145.156 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Methyl aminolevulinate (MAL) is a prodrug that is metabolised to Protoporphyrin IX (sensitizer) used in photodynamic therapy. It is marketed as Metvix.

Metvix cream is applied topically and some time later the skin is illuminated with a proprietary red light (~630 nm) source (Aktilite) to activate the photosensitiser.

Approvals and Indications

Approved in New Zealand for treatment of basal cell carcinoma[1].

It is now approved in many countries and has been used to treat non-melanoma skin cancer (including basal cell carcinoma)[2].

References

  1. ^ http://dermnetnz.org/procedures/metvix-pdt.html "Methyl aminolevulinate photodynamic therapy (MAL PDT)"
  2. ^ http://www.medicalnewstoday.com/articles/36953.php "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006
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