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Methylenedioxyphenethylamine
Systematic (IUPAC) name
2-(1,3-benzodioxol-5-yl)ethanamine
Identifiers
CAS number 1484-85-1
ATC code  ?
PubChem 73874
DrugBank ?
Chemical data
Formula C 9H11NO2  
Mol. mass 165.18914 g/mol
SMILES eMolecules & PubChem
Synonyms 1,3-benzodioxolyl-5-ethanamine;
3,4-methylenedioxy-2-phenylethylamine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Various

3,4-Methylenedioxyphenethylamine (MDPEA), also known as homopiperonylamine, is an entactogen, psychedelic, and stimulant of the substituted phenethylamine and amphetamine chemical classes.

According to Alexander Shulgin in his book PiHKAL, MDPEA appears to be biologically inactive, likely on account of extensive first-pass metabolism by the enzyme monoamine oxidase. However, if MDPEA were either used in high enough of doses (e.g., 1-2 grams), or in combination with a monoamine oxidase inhibitor (MAOI), it is probable that it would become sufficiently active, though it would likely have a relatively short duration of action. This idea is similar in concept to the use of selective MAOA inhibitors and selective MAOB inhibitors in augmentation of dimethyltryptamine (DMT) and phenethylamine (PEA), respectively.

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