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Methyllycaconitine: Wikis


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Systematic (IUPAC) name
CAS number 21019-30-7
ATC code  ?
PubChem 5311278
ChemSpider 4470788
Chemical data
Formula C37H50N2O10
Mol. mass 682.80 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Methyllycaconitine (MLA) is a plant alkaloid found in the larkspur, and has been identified as an antagonist of nicotinic acetylcholine receptors (nAChrs) in the muscle and brain. It is one of many alkaloids found in the larkspur, but is believed to be one of the major culprits in the poisoning of livestock in the Western United States.


Larkspur poisoning in cattle results in labored breathing, rapid and irregular heartbeat, muscular weakness, and collapse.[1] This is believed to be a result of the blockade of nAChrs in the neuromuscular junction, and of antagonism of the α7 nAChrs in the brain.


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