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Methylpentynol: Wikis

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Methylpentynol
Systematic (IUPAC) name
3-methylpent-1-yn-3-ol
Identifiers
CAS number 77-75-8
ATC code N05CM15
PubChem 6494
Chemical data
Formula C 6H10O 
Mol. mass 98.143 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Methylpentynol (Methylparafynol, Dormison, Atemorin) is a hypnotic/sedative with anticonvulsant effects. It was developed in the 1950s,[1] and was previously used for the treatment of insomnia but has been replaced by newer drugs with better safety profiles.[2][3][4][5]

References

  1. ^ Richard Norman Lacey and Hubert Jowitt. Production of Tertiary Acetylenic Alcohols. Patent GB 813,490.
  2. ^ HIRSH HL, ORSINGER WH. Methylparafynol--a new type hypnotic. Preliminary report on its therapeutic efficacy and toxicity. American Practitioner and Digest of Treatment. 1952 Jan;3(1):23-6.
  3. ^ SCHAFFARZICK RW, BROWN BJ. The anticonvulsant activity and toxicity of methylparafynol (dormison) and some other alcohols. Science. 1952 Dec 12;116(3024):663-5.
  4. ^ HERZ A. A new type of hypnotic; unsaturated tertiary carbinols; experimental studies on therapeutic use of 3-methyl-pentin-ol-3 (methylparafynol). Arzneimittelforschung. 1954 Mar;4(3):198-9.
  5. ^ WEAVER LC, ALEXANDER WM, ABREU BE. Anticonvulsant activity of compounds related to methylparafynol. Archives Internationales de Pharmacodynamie et de Therapie. 1961 Apr 1;131:116-22.
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