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Methyprylon: Wikis

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From Wikipedia, the free encyclopedia

1 : 1 mixture (racemate)
Systematic (IUPAC) name
(RS)-3,3-diethyl-5-methylpiperidine-2,4-dione
Identifiers
CAS number 125-64-4
ATC code N05CE02
PubChem 4162
DrugBank APRD00734
Chemical data
Formula C10H17NO2 
Mol. mass 183.248 g/mol
Pharmacokinetic data
Protein binding 60%
Half life 6-16 hours
Therapeutic considerations
Pregnancy cat.  ?
Legal status
 Yes check.svgY(what is this?)  (verify)

Methyprylon is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with fewer side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1965 and the Canadian market in September 1990.

Side effects can include: Skin rash, fever, depression, ulcers or sores in mouth or throat, unusual bleeding or bruising, confusion, fast heartbeat, respiratory depression, swelling of feet or lower legs, dizziness, drowsiness, headache, double vision, clumsiness, constipation, diarrhea, nausea, vomiting, unusual weakness

External links

  • Contos D, Dixon K, Guthrie R, Gerber N, Mays D (1991). "Nonlinear elimination of methyprylon (noludar) in an overdosed patient: correlation of clinical effects with plasma concentration". J Pharm Sci 80 (8): 768–71. doi:10.1002/jps.2600800813. PMID 1686463. 
  • Gwilt P, Pankaskie M, Thornburg J, Zustiak R, Shoenthal D (1985). "Pharmacokinetics of methyprylon following a single oral dose". J Pharm Sci 74 (9): 1001–3. doi:10.1002/jps.2600740920. PMID 2866242. 
  • Lomen P, Linet O (1976). "Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients". J Int Med Res 4 (1): 55–8. PMID 16792. 


Noludar 300mg was still on the market in the 80's it contain methyprylon it wasn't withdrawn for the market in 65

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