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Metirosine
Systematic (IUPAC) name
(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
Identifiers
CAS number 672-87-7
ATC code C02KB01
PubChem 10123
Chemical data
Formula C10H13NO3 
Mol. mass 195.215 g/mol
Pharmacokinetic data
Half life 3.4–3.7 hours
Therapeutic considerations
Pregnancy cat.  ?
Legal status
 Yes check.svgY(what is this?)  (verify)

Metirosine (α-Methyltyrosine, Metyrosine, AMPT) is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which, as a consequence, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body.

Clinical use

Metirosine has been used in the treatment of phaeochromocytoma.[1] It is contra-indicated for the treatment of essential hypertension.

However it is now rarely used in medicine, and its main use is in scientific research, to investigate the effects of catecholamine depletion on behaviour.[2]

See also

References

  1. ^ Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (August 1982). "Alpha-methyltyrosine in the management of phaeochromocytoma". Thorax 37 (8): 632–3. PMID 7179194. 
  2. ^ O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. PMID 17318507
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