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Mezlocillin: Wikis


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Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-6-[[(2 R)-2-[(3-methylsulfonyl-
carboxylic acid
CAS number 51481-65-3
ATC code J01CA10
PubChem 656511
DrugBank APRD01113
Chemical data
Formula C 21H25N5O8S2  
Mol. mass 539.584 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 16–59%
Metabolism Hepatic (20–30%)
Half life 1.3–4.4 hours
Excretion Renal (50%) and biliary
Therapeutic considerations
Pregnancy cat. B
Legal status
Routes Intravenous, intramuscular

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria.


Mechanism of action

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

Susceptible organisms




External links

  • DDB 30377
  • -288358398 at GPnotebook
  • Duke
  • Kristof R, Clusmann H, Koehler W, Fink K, Schramm J (1998). "Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange.". J Neurol Neurosurg Psychiatry 64 (3): 379–81. doi:10.1136/jnnp.64.3.379. PMID 9527154.  
  • McCormick P, Greenslade L, Kibbler C, Chin J, Burroughs A, McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients.". Hepatology 25 (4): 833–6. doi:10.1002/hep.510250408. PMID 9096584.  
  • Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B (1997). "Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure.". Eur J Clin Pharmacol 53 (2): 111–5. doi:10.1007/s002280050347. PMID 9403281.  


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