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Miotine
Miotine.png
IUPAC name
Identifiers
CAS number 4464-16-8
PubChem 46093
SMILES
Properties
Molecular formula C12H18N2O2
Molar mass 222.28 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.[1]

Unlike the miotine analog neostigmine, it doesn't have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood-brain barrier and cause unwanted central nervous system (CNS) side effects.[2]

Miotine equilibrium

References

  1. ^ "http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/2002_Bar-On_Biochem.pdf"
  2. ^ "http://media.wiley.com/product_data/excerpt/72/04700259/0470025972.pdf"
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