She was born in Brisbane, Australia. She graduated in December 2006 from the Queensland Conservatorium in Brisbane with a High Destinction and an Academic Achievement Award obtaining a Bachelor of Music in Performance in Classical Voice. In 2006, Mirusia became the youngest ever winner of the Dame Joan Sutherland Opera Award and went on to record a debut album entitled 'She Walks in Beauty.'
Louwerse has been touring with Dutch violinist and conductor Andre Rieu since 2007 as Soprano Soloist. She is of Dutch descent and can speak Dutch fluently. In May 2008, Andre Rieu and Mirusia released an album entitled 'Waltzing Matilda' in Australia which made it to the number one position on the Australian Music Charts and went platinum within 10 days.