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Molindone
Systematic (IUPAC) name
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-
1,5,6,7-tetrahydro-4H-indol-4-one
Identifiers
CAS number 7416-34-4
ATC code N05AE02
PubChem 23897
Chemical data
Formula C16H24N2O2 
Mol. mass 276.374 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Metabolism Hepatic
Half life 1.5 hours
Excretion Minor, renal and fecal
Therapeutic considerations
Pregnancy cat. C(US)
Legal status -only (US)
Routes Oral
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Molindone (Moban) is a therapeutic antipsychotic, used in the treatment of schizophrenia.[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken by mouth.

It is sometimes described as a typical antipsychotic,[2] and sometimes described as an atypical antipsychotic.[3]

Molindone was discontinued by its sole supplier, Endo Pharmaceuticals, on January 13th 2010. [4]

Adverse effects

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.[3][5]

See also

References

  1. ^ "molindone". F.A. Davis Company. http://www.drugguide.com/monograph_library/psychotropic_drugs/molindone.htm. 
  2. ^ Aparasu RR, Jano E, Johnson ML, Chen H (October 2008). "Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients". Am J Geriatr Pharmacother 6 (4): 198–204. doi:10.1016/j.amjopharm.2008.10.003. PMID 19028375. http://linkinghub.elsevier.com/retrieve/pii/S1543-5946(08)00055-X. 
  3. ^ a b Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). "Molindone for schizophrenia and severe mental illness". Cochrane Database Syst Rev (1): CD002083. doi:10.1002/14651858.CD002083.pub2. PMID 17253473. http://dx.doi.org/10.1002/14651858.CD002083.pub2. 
  4. ^ http://www.fda.gov/Drugs/DrugSafety/DrugShortages/ucm050794.htm
  5. ^ Allison DB, Mentore JL, Heo M, et al. (1999). "Antipsychotic-induced weight gain: a comprehensive research synthesis". Am J Psychiatry 156 (11): 1686–96. PMID 10553730.  Free full text
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