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Moricizine
Systematic (IUPAC) name
ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate
Identifiers
CAS number 31883-05-3
ATC code none
PubChem 34633
DrugBank APRD01124
Chemical data
Formula C 22H25N3O4S 
Mol. mass 427.518 g/mol
Pharmacokinetic data
Bioavailability 38%
Protein binding 95%
Metabolism  ?
Half life 3-4 hours (healthy volunteers), 6-13 hours (cardiac disease)
Excretion  ?
Therapeutic considerations
Pregnancy cat. B (U.S.)
Legal status
Routes  ?

Moricizine is a phenothiazine derivative with Vaughan Williams class Ic antiarrhythmic properties. It undergoes extensive first-pass metabolism, has a bioavailability of 34-38 percent, and is 95 percent bound to plasma proteins. Moricizine is extensively metabolized and may have pharmacologically active metabolites. A recent clinical study has shown that moricizine is slightly less effective than encainide or flecainide in suppressing ventricular premature depolarizations. Compared with disopyramide and quinidine, moricizine was equally or more effective in suppressing ventricular premature depolarizations, couplets, and nonsustained ventricular tachycardia. Further studies are needed comparing moricizine with other class 1 agents in the treatment of life-threatening arrhythmias; available data suggest that moricizine is comparable with these agents in the treatment of ventricular tachycardias and fibrillation. Moricizine appears to have a low incidence of serious adverse effects compared with other antiarrhythmics. This combination of apparently similar efficacy with a decreased incidence of adverse effects makes moricizine a worthwhile addition to currently available antiarrhythmic agents.

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