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Morpheridine: Wikis


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Systematic (IUPAC) name
ethyl 1-(2-morpholin-4-ylethyl)-4-phenyl-piperidine-4-carboxylate
CAS number 469-81-8
ATC code none
PubChem 61121
Chemical data
Formula C 20H30N2O3  
Mol. mass 346.46 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Class A (UK) Schedule I (US)
Routes  ?

Morpheridine (Morpholinoethylnorpethidine) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). It is a strong analgesic with around 4 times the potency of pethidine,[1] and unlike pethidine, does not cause convulsions, although it produces the standard opioid side effects such as sedation and respiratory depression.[2]

Morpheridine is not currently used in medicine and is a Class A/Schedule I drug which is controlled under UN drug conventions.[3]


  1. ^ HOLMES JM. Morpholinoethylnorpethidine hydrochloride in obstetrics. Journal of Obstetrics and Gynaecology in the British Empire. 1958 Feb;65(1):98-9. PMID 13514558
  2. ^ GREEN AF, WARD NB. Analgesic and other properties of morpholinoethylnorpethidine. British Journal of Pharmacology and Chemotherapy. 1956 Mar;11(1):32-4. PMID 13304251
  3. ^ UNODC Bulletin on Narcotics 1958


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