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Updated live from Wikipedia, last check: May 23, 2013 22:55 UTC (55 seconds ago)

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Motexafin lutetium
Motexafin lutetium.png
Other names Antrin; Lu texaphyrin; Lu-Tex; Lutetium texaphyrin; Lutrin; Optrin; PCI 0123
Identifiers
CAS number 246252-04-0
PubChem 3081907
SMILES
Properties
Molecular formula C52H72LuN5O14
Molar mass 1166.12 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc.

It is a photosensitiser for use in photodynamic therapy to treat skin conditions and superficial cancers.

It has also been tested for use in photoangioplasty (photodynamic treatment of diseased arteries).[1]

Clinical trials

Phase II clinical trials were in progress in 1999.[2]

A phase I trial for prostate cancer reported in 2009.[3]

References

  1. ^ Pharmacyclics Announces Final Phase 1 Results of Antrin Phototherapy For Coronary Artery Disease, 2002
  2. ^ Antrin® Photoangioplasty Phase II Clinical Trial Patient Treated During Live Case Demonstration at TCT, 1999
  3. ^ Patel, H; Mick, R; Finlay, J; Zhu, TC; Rickter, E; Cengel, KA; Malkowicz, SB; Hahn, SM et al. (2008). "Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen". Clinical cancer research : an official journal of the American Association for Cancer Research 14 (15): 4869–76. doi:10.1158/1078-0432.CCR-08-0317. PMID 18676760.  







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