| Motoo Kimura | |
|---|---|
 |
|
| Born |
November 13, 1924 Okazaki, Japan |
| Died |
November 13, 1994 |
| Alma mater | University of Wisconsin |
| Doctoral advisor | James F. Crow |
| Other academic advisors | Sewall Wright |
| Known for | development of neutral theory of molecular evolution, and contributions to evolutionary biology, population genetics |
| Notable awards | Darwin Medal of the Royal Society |
Motoo Kimura (木村資生 Kimura Motō), (November 13, 1924 - November 13, 1994) was a Japanese biologist best known for introducing the neutral theory of molecular evolution in 1968.[1] He became one of the most influential theoretical population geneticists. He is remembered in genetics for his innovative use of diffusion equations to calculate the probability of fixation of beneficial, deleterious, or neutral alleles.[2] Combining theoretical population genetics with molecular evolution data, he also developed the neutral theory of molecular evolution in which genetic drift is the main force changing allele frequencies.[3] James F. Crow, himself a renowned population geneticist, considers Kimura to be one of the two greatest evolutionary geneticists, along with Gustave Malécot, after the great trio of the modern synthesis (Haldane, Wright, Fisher).[4]
Kimura was born in Okazaki, Aichi Prefecture. From an early age he was very interested in botany, though he also excelled at mathematics (teaching himself geometry and other maths during a lengthy convalescence due to food poisoning). After entering a selective high school in Nagoya, Kimura focused on plant morphology and cytology; he worked in the laboratory of M. Kumazawa studying the chromosome structure of lilies. With Kumazawa, he also discovered how to connect his interests in botany and mathematics: biometry.[5]
Due to World War II, Kimura left high school early to enter Kyoto Imperial University in 1944. On the advice of the prominent geneticist Hitoshi Kihara, Kimura entered the botany program rather than cytology because the former, in the Faculty of Science rather than Agriculture, allowed him to avoid military duty. He joined Kihara's laboratory after the war, where he studied the introduction of foreign chromosomes into plants and learned the foundations of population genetics. In 1949, Kimura joined the National Institute of Genetics in Mishima, Shizuoka. In 1953 he published his first population genetics paper (which would eventually be very influential), describing a "stepping stone" model for population structure that could treat more complex patterns of immigration than Sewall Wright's earlier "island model". After meeting visiting American geneticist Duncan McDonald (part of Atomic Bomb Casualty Commission), Kimura arranged to enter graduate school at Iowa State College in summer 1953 to study with J. L. Lush.[5]
Kimura soon found Iowa State College too restricting; he moved to the University of Wisconsin to work on stochastic models with James F. Crow and join a strong intellectual community of like-minded geneticists, including Newton Morton and most significantly, Sewall Wright. Near the end of his graduate study, Kimura gave a paper at the 1955 Cold Spring Harbor Symposium; though few were able to understand it (both because of mathematical complexity and Kimura's English pronunciation) it received strong praise from Wright and later J.B.S. Haldane. His accomplishments at Wisconsin included a general model for genetic drift, which could accommodate multiple alleles, selection, migration, and mutations, as well as some work based on R.A. Fisher's fundamental theorem of natural selection. He also built on the work of Wright with the Fokker-Planck equation by introducing the Kolmogorov backward equation to population genetics, allowing the calculation of the probability of a gene to become fixed in a population. He received his PhD in 1956, before returning to Japan (where he would remain for the rest of his life, at the National Institute of Genetics).[5]
Kimura worked on a wide spectrum of theoretical population genetics problems, many of them in collaboration with Takeo Maruyama. He introduced the "infinite allele" and "infinite site" models for the study of genetic drift, both of which would be used widely as the field of molecular evolution grew alongside the number of available peptide and genetic sequences. He also created the "ladder model" that could be applied to electrophoresis studies where homologous proteins differ by whole units of charge. An early statement of his approach was published in 1960, in his An Introduction to Population Genetics.[6] He also contributed an important review article on the ongoing controversy over genetic load in 1961.
1968 marked a turning point in Kimura's career. In that year he introduced the neutral theory of molecular evolution, the idea that, at the molecular level, the large majority of genetic change is neutral with respect to natural selection—making genetic drift a primary factor in evolution.[7] The field of molecular biology was expanding rapidly, and there was growing tension between advocates of the expanding reductionist field and scientists in organismal biology, the traditional domain of evolution. The neutral theory was immediately controversial, receiving support from many molecular biologists and attracting opposition from many evolutionary biologists (though with plenty of divergence from this pattern on both sides, especially among those who studied the theory seriously).
Kimura spent the rest of his life developing and defending the neutral theory. As James Crow put it, "much of Kimura's early work turned out to be pre-adapted for use in the quantitative study of neutral evolution".[5] As new experimental techniques and genetic knowledge became available, Kimura expanded the scope of the neutral theory and created mathematical methods for testing it against the available evidence. In 1973, his colleague Tomoko Ohta developed a more general version of the theory, the "nearly neutral theory", that could account for high volumes of slightly deleterious mutations. Kimura produced a monograph on the neutral theory in 1983, The nearly neutral theory of molecular evoluton, and also worked to promote the theory through popular writings such as My views on evolution, a book that became a best-seller in Japan.[8]
Though difficult to test against alternative selection-centered hypotheses, the neutral theory has become part of modern approaches to molecular evolution.[9]
In 1992, Kimura received the Darwin Medal from the Royal Society, and the following year he was made a Foreign Member of the Royal Society. He was married to Hiroko Kimura. They have one child, a son, Akio, and have a granddaughter, Hanako.[10]
Motoo Kimura (13 November 1924 – 13 November 1994) was a Japanese mathematician and biologist. He was known for introducing the neutral theory of molecular evolution in 1968. "Calculating the rate of evolution in terms of nucleotide substitutions seems to give a value so high that many of the mutations involved must be neutral ones".[1]
He became one of the most influential theoretical population geneticists:
Motoo Kimura's research contributions can be divided into two parts. The first is a series of papers on theoretical population genetics, the quality and quantity of which place him as the successor to the great trinity, R.A. Fisher, J.B.S. Haldane and Sewall Wright. The second is his neutral theory, the idea that the bulk of molecular evolutionary changes are driven by mutation and random chance, rather than by natural selection.[2]
Kimura was heavily influenced by Sewall Wright;[3] the main distinction being that Wright was mainly interested in populations, whereas the core of Motoo's work was in changes at the molecular level. Modified versions of Kimura's ideas are still in use today.
In 1992, Kimura received the Darwin Medal from the Royal Society, and the following year he was made a Foreign Member of the Royal Society.
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