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myogenic factor 6
Symbol MYF6
Alt. symbols HERCULIN, MRF4
Entrez 4618
HUGO 7566
OMIM 159991
RefSeq NM_005593.1
UniProt P23409
Other data
Locus Chr. 12 q21

Myf6, myogenic factor 6 (also known in the medical literature as MRF4 and herculin), is a myogenic regulatory factor (MRF).[1][2]



MYF6 is a member of the myogenic factors (MYF) family that regulate myogenesis and muscle regeneration. Myogenic factor are basic-helix-loop-helix (bHLH) transcription factors

Clinical significance

Mutations in the MYF6 gene are associated with myopathy.[3]

See also


  1. ^ Braun T, Bober E, Winter B, Rosenthal N, Arnold HH (March 1990). "Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12". Embo J. 9 (3): 821–31. PMID 2311584.  
  2. ^ Cupelli L, Renault B, Leblanc-Straceski J, Banks A, Ward D, Kucherlapati RS, Krauter K (1996). "Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106". Cytogenet. Cell Genet. 72 (2-3): 250–1. doi:10.1159/000134201. PMID 8978788.  
  3. ^ Kerst B, Mennerich D, Schuelke M, Stoltenburg-Didinger G, von Moers A, Gossrau R, van Landeghem FK, Speer A, Braun T, Hübner C (December 2000). "Heterozygous myogenic factor 6 mutation associated with myopathy and severe course of Becker muscular dystrophy". Neuromuscul. Disord. 10 (8): 572–7. doi:10.1016/S0960-8966(00)00150-4. PMID 11053684.  


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