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N-Arachidonoyl dopamine
NADA.png
IUPAC name
Other names NADA
Identifiers
CAS number 199875-69-9
PubChem 5282105
SMILES
Properties
Molecular formula C28H41NO3
Molar mass 439.63 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

N-Arachidonoyl dopamine (NADA) is an endocannabinoid which acts as an agonist of the CB1 receptor[1] and the transient receptor potential V1 (TRPV1) ion channel. Its discovery was described in 2002 by an academic research group from Italy and the USA. It was found in the brain of rats, with especially high concentrations in the hippocampus, cerebellum and striatum. It activates the TRPV1 channel with an EC50 of approximately of 50 nM. The high potency makes it the putative endogenous TRPV1 agonist.[2]

See also

References

  1. ^ Ralevic V. (July 2003). "Cannabinoid modulation of peripheral autonomic and sensory neurotransmission.". European journal of pharmacology 472 (1-2): 1–21. doi:10.1016/S0014-2999(03)01813-2. PMID 12860468.  
  2. ^ Huang SM, Bisogno T, Trevisani M, et al. (June 2002). "An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors". Proceedings of the National Academy of Sciences of the United States of America 99 (12): 8400–5. doi:10.1073/pnas.122196999. PMID 12060783.  

External links

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