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NAN-190: Wikis

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NAN-190
Systematic (IUPAC) name
1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
Identifiers
CAS number 115388-32-4
ATC code  ?
PubChem 4431
Chemical data
Formula C 23H27N3O3  
Mol. mass 393.478 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

NAN-190 is a drug and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor antagonist, but a subsequent discovery showed that it also potently blocks the α2-adrenergic receptor.[1] The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin receptor antagonist.[1]

References

  1. ^ a b Foong JP, Bornstein JC. (2009). "5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig.". Neuroreport. 20 (3): 325–330. PMID 19190523.  
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