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NBQX
NBQX.png
IUPAC name
Identifiers
CAS number 118876-58-7
PubChem 3272524
SMILES
Properties
Molecular formula C12H8N4O6S
Molar mass 336.281
Appearance brown/red powder
Solubility in water Soluble to 100 mM in DMSO
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione) is an AMPA receptor antagonist.

Disodium salt version can be dissolved in water at higher concentrations (<30 mmol).

Blocks AMPA receptors in micromolar concentrations (~10–20 µmol) and also kainate receptors. In experiments it is used to counter glutamate excitotoxicity.[1] NBQX has anticonvulsant activity in rodent seizure models. [2]

References

  1. ^ Pitt, D.; Werner, P.; Raine, C. S. (2000). "Glutamate excitotoxicity in a model of multiple sclerosis". Nat Med. 6 (1): 67–70.
  2. ^ Yamaguchi, S.; Donevan, S.D.; Rogawski, M.A. (1993). Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. Epilepsy Res. 15:179–184.
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