The Full Wiki

NCOA4: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Nuclear receptor coactivator 4
Identifiers
Symbols NCOA4; ARA70; DKFZp762E1112; ELE1; PTC3; RFG
External IDs OMIM601984 MGI1350932 HomoloGene38052 GeneCards: NCOA4 Gene
RNA expression pattern
PBB GE NCOA4 210774 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8031 27057
Ensembl ENSG00000138293 ENSMUSG00000056234
UniProt Q13772 n/a
RefSeq (mRNA) NM_005437 NM_001033988
RefSeq (protein) NP_005428 NP_001029160
Location (UCSC) Chr 10:
51.24 - 51.26 Mb
Chr 14:
31 - 31.01 Mb
PubMed search [1] [2]

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]

Contents

Interactions

NCOA4 has been shown to interact with Peroxisome proliferator-activated receptor gamma[4] and Androgen receptor.[5][2][6][7][8][9][10][11][12]

References

  1. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (Feb 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261.  
  2. ^ a b Yeh S, Chang C (Jul 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A 93 (11): 5517–21. PMID 8643607.  
  3. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031.  
  4. ^ Heinlein, C A; Ting H J, Yeh S, Chang C (Jun. 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J. Biol. Chem. (UNITED STATES) 274 (23): 16147–52. ISSN 0021-9258. PMID 10347167.  
  5. ^ Alen, P; Claessens F, Schoenmakers E, Swinnen J V, Verhoeven G, Rombauts W, Peeters B (Jan. 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Mol. Endocrinol. (UNITED STATES) 13 (1): 117–28. ISSN 0888-8809. PMID 9892017.  
  6. ^ Miyamoto, H; Yeh S, Wilding G, Chang C (Jun. 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (13): 7379–84. ISSN 0027-8424. PMID 9636157.  
  7. ^ Lin, H K; Yeh S, Kang H Y, Chang C (Jun. 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (13): 7200–5. doi:10.1073/pnas.121173298. ISSN 0027-8424. PMID 11404460.  
  8. ^ Yeh, S; Lin H K, Kang H Y, Thin T H, Lin M F, Chang C (May. 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (10): 5458–63. ISSN 0027-8424. PMID 10318905.  
  9. ^ Zhou, Zhong-xun; He Bin, Hall Susan H, Wilson Elizabeth M, French Frank S (Feb. 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Mol. Endocrinol. (United States) 16 (2): 287–300. ISSN 0888-8809. PMID 11818501.  
  10. ^ He, Bin; Minges John T, Lee Lori W, Wilson Elizabeth M (Mar. 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. (United States) 277 (12): 10226–35. doi:10.1074/jbc.M111975200. ISSN 0021-9258. PMID 11779876.  
  11. ^ Gao, T; Brantley K, Bolu E, McPhaul M J (Oct. 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Mol. Endocrinol. (UNITED STATES) 13 (10): 1645–56. ISSN 0888-8809. PMID 10517667.  
  12. ^ He, Bin; Wilson Elizabeth M (Mar. 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. (United States) 23 (6): 2135–50. ISSN 0270-7306. PMID 12612084.  

See also

External links

Further reading

  • Minoletti F, Butti MG, Coronelli S, et al. (1995). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2.". Genes Chromosomes Cancer 11 (1): 51–7. doi:10.1002/gcc.2870110108. PMID 7529046.  
  • Jhiang SM, Smanik PA, Mazzaferri EL (1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma.". Cancer Lett. 78 (1-3): 69–76. doi:10.1016/0304-3835(94)90033-7. PMID 8180971.  
  • Bongarzone I, Butti MG, Coronelli S, et al. (1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.". Cancer Res. 54 (11): 2979–85. PMID 8187085.  
  • Bongarzone I, Butti MG, Fugazzola L, et al. (1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.". Genomics 42 (2): 252–9. doi:10.1006/geno.1997.4685. PMID 9192845.  
  • Miyamoto H, Yeh S, Wilding G, Chang C (1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMID 9636157.  
  • Alen P, Claessens F, Schoenmakers E, et al. (1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform.". Mol. Endocrinol. 13 (1): 117–28. doi:10.1210/me.13.1.117. PMID 9892017.  
  • Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.". J. Biol. Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.  
  • Yeh S, Lin HK, Kang HY, et al. (1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMID 10318905.  
  • Heinlein CA, Ting HJ, Yeh S, Chang C (1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.". J. Biol. Chem. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.  
  • Gao T, Brantley K, Bolu E, McPhaul MJ (1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays.". Mol. Endocrinol. 13 (10): 1645–56. doi:10.1210/me.13.10.1645. PMID 10517667.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.  
  • Lin HK, Yeh S, Kang HY, Chang C (2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMID 11404460.  
  • Basolo F, Giannini R, Monaco C, et al. (2002). "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.". Am. J. Pathol. 160 (1): 247–54. PMID 11786418.  
  • Zhou ZX, He B, Hall SH, et al. (2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR).". Mol. Endocrinol. 16 (2): 287–300. doi:10.1210/me.16.2.287. PMID 11818501.  
  • Thin TH, Kim E, Yeh S, et al. (2002). "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation.". J. Biol. Chem. 277 (39): 36499–508. doi:10.1074/jbc.M202824200. PMID 12068007.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message