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Natural cytotoxicity triggering receptor 3
Symbols NCR3; 1C7; CD337; LY117; NKp30
External IDs HomoloGene51827 GeneCards: NCR3 Gene
RNA expression pattern
PBB GE NCR3 211010 s at tn.png
PBB GE NCR3 210763 x at tn.png
PBB GE NCR3 211583 x at tn.png
More reference expression data
Species Human Mouse
Entrez 259197 n/a
Ensembl ENSG00000204475 n/a
UniProt O14931 n/a
RefSeq (mRNA) NM_147130 n/a
RefSeq (protein) NP_667341 n/a
Location (UCSC) Chr 6:
31.66 - 31.67 Mb
PubMed search [1] n/a

Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the NCR3 gene.[1][2][3] NCR3 has also been designated as CD337 (cluster of differentiation 337).


  1. ^ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Mar 1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics 31 (2): 215-22. doi:10.1006/geno.1996.0034. PMID 8824804.  
  2. ^ Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T (Jan 2002). "Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells". Tissue Antigens 58 (4): 255-8. PMID 11782277.  
  3. ^ "Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3".  

Further reading

  • Djeu JY, Jiang K, Wei S (2002). "A view to a kill: signals triggering cytotoxicity.". Clin. Cancer Res. 8 (3): 636–40. PMID 11895890.  
  • Holzinger I, de Baey A, Messer G, et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region.". Immunogenetics 42 (5): 315–22. doi:10.1007/BF00179392. PMID 7590964.  
  • de Baey A, Fellerhoff B, Maier S, et al. (1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.". Genomics 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684.  
  • Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.". J. Immunol. 162 (8): 4745–54. PMID 10202016.  
  • Pende D, Parolini S, Pessino A, et al. (1999). "Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.". J. Exp. Med. 190 (10): 1505–16. doi:10.1084/jem.190.10.1505. PMID 10562324.  
  • Sivakamasundari R, Raghunathan A, Zhang CY, et al. (2000). "Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC.". Immunogenetics 51 (8-9): 723–32. doi:10.1007/s002510000192. PMID 10941844.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Le Bouteiller P, Barakonyi A, Giustiniani J, et al. (2003). "Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16963–8. doi:10.1073/pnas.012681099. PMID 12486241.  
  • Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells.". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity.". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045.  
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.". Blood 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.  
  • Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors.". J. Immunol. 174 (5): 2653–60. PMID 15728472.  
  • Vitale M, Della Chiesa M, Carlomagno S, et al. (2005). "NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.". Blood 106 (2): 566–71. doi:10.1182/blood-2004-10-4035. PMID 15784725.  
  • Warren HS, Jones AL, Freeman C, et al. (2005). "Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan.". J. Immunol. 175 (1): 207–12. PMID 15972650.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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