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Neurogenic differentiation 2
Symbols NEUROD2; MGC26304; NDRF
External IDs OMIM601725 MGI107755 HomoloGene4489 GeneCards: NEUROD2 Gene
RNA expression pattern
PBB GE NEUROD2 210271 at tn.png
More reference expression data
Species Human Mouse
Entrez 4761 18013
Ensembl ENSG00000171532 ENSMUSG00000038255
UniProt Q15784 Q3TYB2
RefSeq (mRNA) NM_006160 NM_010895
RefSeq (protein) NP_006151 NP_035025
Location (UCSC) Chr 17:
35.01 - 35.02 Mb
Chr 11:
98.14 - 98.15 Mb
PubMed search [1] [2]

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]



NEUROD2 has been shown to interact with Protein kinase N1.[3]


  1. ^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Apr 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.  
  2. ^ a b "Entrez Gene: NEUROD2 neurogenic differentiation 2".  
  3. ^ Shibata, H; Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec. 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res. (NETHERLANDS) 74 (1-2): 126–34. ISSN 0169-328X. PMID 10640683.  

Further reading

  • McCormick MB, Tamimi RM, Snider L, et al. (1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.". Mol. Cell. Biol. 16 (10): 5792–800. PMID 8816493.  
  • Kume H, Maruyama K, Shinozaki K, et al. (1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein.". Brain Res. Mol. Brain Res. 60 (1): 107–14. doi:10.1016/S0169-328X(98)00176-4. PMID 9748526.  
  • Kitamura T, Miyachi T, Nakamura S, Kawakami H (1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1.". Biochim. Biophys. Acta 1445 (1): 142–7. PMID 10209266.  
  • Shibata H, Oda H, Mukai H, et al. (2000). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2.". Brain Res. Mol. Brain Res. 74 (1-2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.  
  • Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53.". Genomics 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.  
  • Franklin A, Kao A, Tapscott S, Unis A (2002). "NeuroD homologue expression during cortical development in the human brain.". J. Child Neurol. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772.  
  • Westerman BA, Poutsma A, Maruyama K, et al. (2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.". Mech. Dev. 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Westerman BA, Chhatta A, Poutsma A, et al. (2004). "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells.". Biochim. Biophys. Acta 1676 (1): 96–103. PMID 14732494.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zill P, Büttner A, Eisenmenger W, Bondy B (2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior.". Mol. Psychiatry 11 (6): 525–7. doi:10.1038/ PMID 16607387.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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