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Neurogenic differentiation 2
Identifiers
Symbols NEUROD2; MGC26304; NDRF
External IDs OMIM601725 MGI107755 HomoloGene4489 GeneCards: NEUROD2 Gene
RNA expression pattern
PBB GE NEUROD2 210271 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4761 18013
Ensembl ENSG00000171532 ENSMUSG00000038255
UniProt Q15784 Q3TYB2
RefSeq (mRNA) NM_006160 NM_010895
RefSeq (protein) NP_006151 NP_035025
Location (UCSC) Chr 17:
35.01 - 35.02 Mb
Chr 11:
98.14 - 98.15 Mb
PubMed search [1] [2]

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]

Contents

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.[3]

References

  1. ^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Apr 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.  
  2. ^ a b "Entrez Gene: NEUROD2 neurogenic differentiation 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4761.  
  3. ^ Shibata, H; Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec. 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res. (NETHERLANDS) 74 (1-2): 126–34. ISSN 0169-328X. PMID 10640683.  

Further reading

  • McCormick MB, Tamimi RM, Snider L, et al. (1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.". Mol. Cell. Biol. 16 (10): 5792–800. PMID 8816493.  
  • Kume H, Maruyama K, Shinozaki K, et al. (1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein.". Brain Res. Mol. Brain Res. 60 (1): 107–14. doi:10.1016/S0169-328X(98)00176-4. PMID 9748526.  
  • Kitamura T, Miyachi T, Nakamura S, Kawakami H (1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1.". Biochim. Biophys. Acta 1445 (1): 142–7. PMID 10209266.  
  • Shibata H, Oda H, Mukai H, et al. (2000). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2.". Brain Res. Mol. Brain Res. 74 (1-2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.  
  • Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53.". Genomics 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.  
  • Franklin A, Kao A, Tapscott S, Unis A (2002). "NeuroD homologue expression during cortical development in the human brain.". J. Child Neurol. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772.  
  • Westerman BA, Poutsma A, Maruyama K, et al. (2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.". Mech. Dev. 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Westerman BA, Chhatta A, Poutsma A, et al. (2004). "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells.". Biochim. Biophys. Acta 1676 (1): 96–103. PMID 14732494.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zill P, Büttner A, Eisenmenger W, Bondy B (2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior.". Mol. Psychiatry 11 (6): 525–7. doi:10.1038/sj.mp.4001825. PMID 16607387.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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