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neurogenin 3
Symbols NEUROG3; Math4B; Atoh5; ngn3; bHLHa7
External IDs OMIM604882 MGI893591 HomoloGene40692 GeneCards: NEUROG3 Gene
Species Human Mouse
Entrez 50674 11925
Ensembl ENSG00000122859 ENSMUSG00000044312
UniProt Q9Y4Z2 P70661
RefSeq (mRNA) NM_020999 NM_009719
RefSeq (protein) NP_066279 NP_033849
Location (UCSC) Chr 10:
71 - 71 Mb
Chr 10:
61.6 - 61.6 Mb
PubMed search [1] [2]

Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.[1]

Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine.[2] It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.[3]

In pancreas and brain the major splicing isoform does not code for a protein, potentially a regulatory mechanism as overexpression of the protein causes exit from cell cycle and depletion of the progenitor pool.[4]


  1. ^ "Entrez Gene: neurogenin 3". 
  2. ^ Wang J, Cortina G, Wu SV, Tran R, Cho JH, Tsai MJ, Bailey TJ, Jamrich M, Ament ME, Treem WR, Hill ID, Vargas JH, Gershman G, Farmer DG, Reyen L, Martín MG (July 2006). "Mutant neurogenin-3 in congenital malabsorptive diarrhea". N. Engl. J. Med. 355 (3): 270–80. doi:10.1056/NEJMoa054288. PMID 16855267. 
  3. ^ Gradwohl G, Dierich A, LeMeur M, Guillemot F (February 2000). "neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas". Proc. Natl. Acad. Sci. U.S.A. 97 (4): 1607–11. PMID 10677506. 
  4. ^ Kanadia RN, Cepko CL (February 2010). "Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development". Genes Dev. 24 (3): 229–34. doi:10.1101/gad.1847110. PMID 20080942. 

Further reading

  • Lejonklou MH, Edfeldt K, Johansson TA, et al. (2009). "Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells.". Pancreas 38 (3): 259-66. doi:10.1097/MPA.0b013e3181930818. PMID 19307926. 
  • del Bosque-Plata L, Lin J, Horikawa Y, et al. (2001). "Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.". Diabetes 50 (3): 694-6. PMID 11246894. 
  • Cauchi S, Proença C, Choquet H, et al. (2008). "Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.". J. Mol. Med. 86 (3): 341-8. doi:10.1007/s00109-007-0295-x. PMID 18210030. 
  • Jensen JN, Hansen L, Ekstrøm CT, et al. (2001). "Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population.". Diabetologia 44 (1): 123-6. PMID 11206403. 
  • Cauchi S, Meyre D, Durand E, et al. (2008). "Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.". PLoS ONE 3 (5): e2031. doi:10.1371/journal.pone.0002031. PMID 18461161. 
  • Louet JF, Smith SB, Gautier JF, et al. (2008). "Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes.". Diabetes Obes Metab 10 (10): 912-20. doi:10.1111/j.1463-1326.2007.00830.x. PMID 18093211. 
  • Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.". Diabetes 55 (8): 2379-86. doi:10.2337/db05-1203. PMID 16873704. 
  • Milord E, Gragnoli C (2006). "NEUROG3 variants and type 2 diabetes in Italians.". Minerva Med. 97 (5): 373-8. PMID 17146417. 
  • Li J, Bergmann A, Reimann M, et al. (2008). "Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes.". Exp. Clin. Endocrinol. Diabetes 116 (3): 178-83. doi:10.1055/s-2007-992156. PMID 18072012. 
  • Dror V, Nguyen V, Walia P, et al. (2007). "Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells.". Diabetologia 50 (12): 2504-15. doi:10.1007/s00125-007-0835-5. PMID 17922104. 
  • Heremans Y, Van De Casteele M, in't Veld P, et al. (2002). "Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.". J. Cell Biol. 159 (2): 303-12. doi:10.1083/jcb.200203074. PMID 12403815. 
  • Jackson AE, Cassell PG, North BV, et al. (2004). "Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population.". Diabetes 53 (8): 2122-5. PMID 15277395. 
  • Drenos F, Talmud PJ, Casas JP, et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.". Hum. Mol. Genet. 18 (12): 2305-16. doi:10.1093/hmg/ddp159. PMID 19336475. 
  • Okada T, Tobe K, Hara K, et al. (2001). "Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects.". Diabetologia 44 (2): 241-4. PMID 11270683. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sommer L, Ma Q, Anderson DJ (1996). "neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS.". Mol. Cell. Neurosci. 8 (4): 221-41. doi:10.1006/mcne.1996.0060. PMID 9000438. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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