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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

PDB rendering based on 1a02.
Available structures
1a02, 1owr, 1p7h, 1pzu, 1s9k, 2as5
Symbols NFATC2; KIAA0611; NFAT1; NFATP
External IDs OMIM600490 MGI102463 HomoloGene7861 GeneCards: NFATC2 Gene
Species Human Mouse
Entrez 4773 18019
Ensembl ENSG00000101096 ENSMUSG00000027544
UniProt Q13469 Q6P3F6
RefSeq (mRNA) NM_012340 NM_001037177
RefSeq (protein) NP_036472 NP_001032254
Location (UCSC) Chr 20:
49.44 - 49.59 Mb
Chr 2:
168.17 - 168.29 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.[1]

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]



NFATC2 has been shown to interact with MEF2D,[3] EP300,[4] IRF4[5] and Protein kinase Mζ.[6]

See also


  1. ^ Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jul 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature 369 (6480): 497–502. doi:10.1038/369497a0. PMID 8202141.  
  2. ^ "Entrez Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2".  
  3. ^ Youn, H D; Chatila T A, Liu J O (Aug. 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". EMBO J. (ENGLAND) 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. ISSN 0261-4189. PMID 10944115.  
  4. ^ García-Rodríguez, C; Rao A (Jun. 1998). "Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)". J. Exp. Med. (UNITED STATES) 187 (12): 2031–6. ISSN 0022-1007. PMID 9625762.  
  5. ^ Rengarajan, Jyothi; Mowen Kerri A, McBride Kathryn D, Smith Erica D, Singh Harinder, Glimcher Laurie H (Apr. 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. (United States) 195 (8): 1003–12. ISSN 0022-1007. PMID 11956291.  
  6. ^ San-Antonio, Belén; Iñiguez Miguel A, Fresno Manuel (Jul. 2002). "Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity". J. Biol. Chem. (United States) 277 (30): 27073–80. doi:10.1074/jbc.M106983200. ISSN 0021-9258. PMID 12021260.  

Further reading

  • Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function.". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.  
  • Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.". Cell 96 (5): 611–4. PMID 10089876.  
  • Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation.". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.  
  • Aramburu J, Azzoni L, Rao A, Perussia B (1995). "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding.". J. Exp. Med. 182 (3): 801–10. PMID 7650486.  
  • Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.  
  • Li X, Ho SN, Luna J, et al. (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp.". Cytogenet. Cell Genet. 68 (3-4): 185–91. PMID 7842733.  
  • Ho S, Timmerman L, Northrop J, Crabtree GR (1995). "Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.". Adv. Exp. Med. Biol. 365: 167–73. PMID 7887301.  
  • Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.". Eur. J. Immunol. 24 (11): 2646–52. PMID 7957556.  
  • Vacca A, Farina M, Maroder M, et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.  
  • Jain J, McCaffrey PG, Miner Z, et al. (1993). "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.". Nature 365 (6444): 352–5. doi:10.1038/365352a0. PMID 8397339.  
  • Luo C, Burgeon E, Carew JA, et al. (1996). "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.". Mol. Cell. Biol. 16 (7): 3955–66. PMID 8668213.  
  • Di Somma MM, Majolini MB, Burastero SE, et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.". Eur. J. Immunol. 26 (9): 2181–8. PMID 8814265.  
  • Copeland KF, McKay PJ, Rosenthal KL (1996). "Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element.". AIDS Res. Hum. Retroviruses 12 (2): 143–8. PMID 8834464.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.  
  • Hodge MR, Chun HJ, Rengarajan J, et al. (1997). "NF-AT-Driven interleukin-4 transcription potentiated by NIP45.". Science 274 (5294): 1903–5. PMID 8943202.  
  • Lyakh L, Ghosh P, Rice NR (1997). "Expression of NFAT-family proteins in normal human T cells.". Mol. Cell. Biol. 17 (5): 2475–84. PMID 9111316.  
  • Amasaki Y, Masuda ES, Imamura R, et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets.". J. Immunol. 160 (5): 2324–33. PMID 9498773.  
  • Chen L, Glover JN, Hogan PG, et al. (1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.". Nature 392 (6671): 42–8. doi:10.1038/32100. PMID 9510247.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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