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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
External IDs OMIM602698 MGI103296 HomoloGene27827 GeneCards: NFATC3 Gene
RNA expression pattern
PBB GE NFATC3 210555 s at tn.png
PBB GE NFATC3 207416 s at tn.png
PBB GE NFATC3 210556 at tn.png
More reference expression data
Species Human Mouse
Entrez 4775 18021
Ensembl ENSG00000072736 ENSMUSG00000031902
UniProt Q12968 Q3TTU5
RefSeq (mRNA) NM_004555 NM_010901
RefSeq (protein) NP_004546 NP_035031
Location (UCSC) Chr 16:
66.68 - 66.82 Mb
Chr 8:
108.95 - 109.02 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[1][2]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]


See also


  1. ^ Hoey T, Sun YL, Williamson K, Xu X (Jun 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461-72. PMID 7749981.  
  2. ^ a b "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".  

Further reading

  • Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function.". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.  
  • Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.". Cell 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.  
  • Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation.". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.  
  • Masuda ES, Naito Y, Tokumitsu H, et al. (1995). "NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.". Mol. Cell. Biol. 15 (5): 2697–706. PMID 7739550.  
  • Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.". Eur. J. Immunol. 24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID 7957556.  
  • Vacca A, Farina M, Maroder M, et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.  
  • Di Somma MM, Majolini MB, Burastero SE, et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.". Eur. J. Immunol. 26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID 8814265.  
  • Masuda ES, Liu J, Imamura R, et al. (1997). "Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain.". Mol. Cell. Biol. 17 (4): 2066–75. PMID 9121455.  
  • Chow CW, Rincón M, Cavanagh J, et al. (1997). "Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.". Science 278 (5343): 1638–41. doi:10.1126/science.278.5343.1638. PMID 9374467.  
  • Amasaki Y, Masuda ES, Imamura R, et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets.". J. Immunol. 160 (5): 2324–33. PMID 9498773.  
  • Zhu J, Shibasaki F, Price R, et al. (1998). "Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.". Cell 93 (5): 851–61. doi:10.1016/S0092-8674(00)81445-2. PMID 9630228.  
  • Aramburu J, Garcia-Cózar F, Raghavan A, et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.". Mol. Cell 1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.  
  • Imamura R, Masuda ES, Naito Y, et al. (1998). "Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells.". J. Immunol. 161 (7): 3455–63. PMID 9759864.  
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.  
  • Amasaki Y, Adachi S, Ishida Y, et al. (2002). "A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells.". J. Biol. Chem. 277 (28): 25640–8. doi:10.1074/jbc.M201860200. PMID 11997392.  
  • Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMID 12417987.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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