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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Symbols NFATC4; NF-ATc4; NFAT3
External IDs OMIM602699 MGI1920431 HomoloGene3349 GeneCards: NFATC4 Gene
RNA expression pattern
PBB GE NFATC4 213345 at tn.png
PBB GE NFATC4 205897 at tn.png
More reference expression data
Species Human Mouse
Entrez 4776 73181
Ensembl ENSG00000100968 n/a
UniProt Q14934 n/a
RefSeq (mRNA) NM_004554 NM_023699
RefSeq (protein) NP_004545 NP_076188
Location (UCSC) Chr 14:
23.91 - 23.92 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[1][2]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[2]



NFATC4 has been shown to interact with CREB binding protein.[3]

See also


  1. ^ Hoey T, Sun YL, Williamson K, Xu X (Jun 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. PMID 7749981.  
  2. ^ a b "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".  
  3. ^ Yang, T; Davis R J, Chow C W (Oct. 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". J. Biol. Chem. (United States) 276 (43): 39569–76. doi:10.1074/jbc.M102961200. ISSN 0021-9258. PMID 11514544.  

Further reading

  • Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function.". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.  
  • Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.". Cell 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.  
  • Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation.". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.  
  • Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.". Eur. J. Immunol. 24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID 7957556.  
  • Vacca A, Farina M, Maroder M, et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.  
  • Di Somma MM, Majolini MB, Burastero SE, et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.". Eur. J. Immunol. 26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID 8814265.  
  • Molkentin JD, Lu JR, Antos CL, et al. (1998). "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.". Cell 93 (2): 215–28. doi:10.1016/S0092-8674(00)81573-1. PMID 9568714.  
  • Aramburu J, Garcia-Cózar F, Raghavan A, et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.". Mol. Cell 1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.  
  • Chow CW, Davis RJ (2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3.". Mol. Cell. Biol. 20 (2): 702–12. doi:10.1128/MCB.20.2.702-712.2000. PMID 10611249.  
  • Graef IA, Chen F, Chen L, et al. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.". Cell 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183.  
  • Yang T, Davis RJ, Chow CW (2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation.". J. Biol. Chem. 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544.  
  • Yang TT, Xiong Q, Enslen H, et al. (2002). "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.". Mol. Cell. Biol. 22 (11): 3892–904. doi:10.1128/MCB.22.11.3892-3904.2002. PMID 11997522.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.  
  • Graef IA, Wang F, Charron F, et al. (2003). "Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.". Cell 113 (5): 657–70. doi:10.1016/S0092-8674(03)00390-8. PMID 12787506.  
  • Lahti AL, Manninen A, Saksela K (2003). "Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB.". Virology 310 (1): 190–6. doi:10.1016/S0042-6822(03)00164-8. PMID 12788643.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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