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NFE2: Wikis


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Nuclear factor (erythroid-derived 2), 45kDa
Symbols NFE2; NF-E2; p45
External IDs OMIM601490 MGI97308 HomoloGene4491 GeneCards: NFE2 Gene
RNA expression pattern
PBB GE NFE2 209930 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4778 18022
Ensembl ENSG00000123405 ENSMUSG00000058794
UniProt Q16621 n/a
RefSeq (mRNA) NM_006163 NM_008685
RefSeq (protein) NP_006154 NP_032711
Location (UCSC) Chr 12:
52.97 - 52.98 Mb
Chr 15:
103.08 - 103.08 Mb
PubMed search [1] [2]

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.[1][2]



NFE2 has been shown to interact with CREB binding protein.[3]


  1. ^ Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol 13 (9): 5604–12. PMID 8355703.  
  2. ^ "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".  
  3. ^ Hung, H L; Kim A Y, Hong W, Rakowski C, Blobel G A (Apr. 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. (United States) 276 (14): 10715–21. doi:10.1074/jbc.M007846200. ISSN 0021-9258. PMID 11154691.  

Further reading

  • Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.". Mol. Cell. Biol. 12 (5): 2135–42. PMID 1569944.  
  • Pischedda C, Cocco S, Melis A, et al. (1995). "Isolation of a differentially regulated splicing isoform of human NF-E2.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3511–5. doi:10.1073/pnas.92.8.3511. PMID 7724591.  
  • Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, et al. (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.". Cell 81 (5): 695–704. doi:10.1016/0092-8674(95)90531-6. PMID 7774011.  
  • Igarashi K, Kataoka K, Itoh K, et al. (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins.". Nature 367 (6463): 568–72. doi:10.1038/367568a0. PMID 8107826.  
  • Chan JY, Han XL, Kan YW (1994). "Isolation of cDNA encoding the human NF-E2 protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11366–70. doi:10.1073/pnas.90.23.11366. PMID 8248255.  
  • Toki T, Itoh J, Kitazawa J, et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.  
  • Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.". Blood 89 (11): 3925–35. PMID 9166829.  
  • Gavva NR, Gavva R, Ermekova K, et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II.". J. Biol. Chem. 272 (39): 24105–8. doi:10.1074/jbc.272.39.24105. PMID 9305852.  
  • Mosser EA, Kasanov JD, Forsberg EC, et al. (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains.". Biochemistry 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.  
  • Hung HL, Kim AY, Hong W, et al. (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.  
  • Gavva NR, Wen SC, Daftari P, et al. (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.". Genomics 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.  
  • Boulanger L, Sabatino DE, Wong EY, et al. (2003). "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins.". J. Biol. Chem. 277 (44): 41563–70. doi:10.1074/jbc.M208184200. PMID 12196550.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Marini MG, Asunis I, Chan K, et al. (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.". Blood Cells Mol. Dis. 29 (2): 145–58. doi:10.1006/bcmd.2002.0550. PMID 12490281.  
  • Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling.". J. Biol. Chem. 278 (10): 8163–71. doi:10.1074/jbc.M209612200. PMID 12509425.  
  • Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays.". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.  
  • Chuen CK, Li K, Yang M, et al. (2004). "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells.". J. Lab. Clin. Med. 143 (2): 75–88. doi:10.1016/j.lab.2003.09.006. PMID 14966463.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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