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NFE2L1: Wikis


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From Wikipedia, the free encyclopedia

Nuclear factor (erythroid-derived 2)-like 1
Symbols NFE2L1; FLJ00380; LCR-F1; NRF1; TCF11
External IDs OMIM163260 MGI99421 HomoloGene20685 GeneCards: NFE2L1 Gene
RNA expression pattern
PBB GE NFE2L1 214179 s at tn.png
PBB GE NFE2L1 200758 s at tn.png
PBB GE NFE2L1 200759 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4779 18023
Ensembl ENSG00000082641 ENSMUSG00000038615
UniProt Q14494 Q3U4L3
RefSeq (mRNA) NM_003204 NM_008686
RefSeq (protein) NP_003195 NP_032712
Location (UCSC) Chr 17:
43.48 - 43.49 Mb
Chr 11:
96.63 - 96.65 Mb
PubMed search [1] [2]

Nuclear factor erythroid 2-related factor 1 is a protein that in humans is encoded by the NFE2L1 gene.[1][2][3]



NFE2L1 has been shown to interact with C-jun.[4]


  1. ^ Chan JY, Han XL, Kan YW (Jan 1994). "Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast". Proc Natl Acad Sci U S A 90 (23): 11371–5. PMID 8248256.  
  2. ^ Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TS, Kan YW (Apr 1998). "Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice". EMBO J 17 (6): 1779–87. doi:10.1093/emboj/17.6.1779. PMID 9501099.  
  3. ^ "Entrez Gene: NFE2L1 nuclear factor (erythroid-derived 2)-like 1".  
  4. ^ Venugopal, R; Jaiswal A K (Dec. 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene (ENGLAND) 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. ISSN 0950-9232. PMID 9872330.  

Further reading

  • Luna L, Skammelsrud N, Johnsen O, et al. (1995). "Structural organization and mapping of the human TCF11 gene.". Genomics 27 (2): 237–44. doi:10.1006/geno.1995.1037. PMID 7557987.  
  • Luna L, Johnsen O, Skartlien AH, et al. (1995). "Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22.". Genomics 22 (3): 553–62. doi:10.1006/geno.1994.1428. PMID 8001966.  
  • Caterina JJ, Donze D, Sun CW, et al. (1994). "Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.". Nucleic Acids Res. 22 (12): 2383–91. PMID 8036168.  
  • Johnsen O, Skammelsrud N, Luna L, et al. (1996). "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.". Nucleic Acids Res. 24 (21): 4289–97. PMID 8932385.  
  • Toki T, Itoh J, Kitazawa J, et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.  
  • Johnsen O, Murphy P, Prydz H, Kolsto AB (1998). "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription.". Nucleic Acids Res. 26 (2): 512–20. PMID 9421508.  
  • Novotny V, Prieschl EE, Csonga R, et al. (1999). "Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells.". Nucleic Acids Res. 26 (23): 5480–5. PMID 9826775.  
  • Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.  
  • Murphy P, Kolstø A (2001). "Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development.". Mech. Dev. 97 (1-2): 141–8. PMID 11025215.  
  • Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647–52. PMID 12358155.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Husberg C, Murphy P, Bjørgo E, et al. (2003). "Cellular localisation and nuclear export of the human bZIP transcription factor TCF11.". Biochim. Biophys. Acta 1640 (2-3): 143–51. PMID 12729924.  
  • Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays.". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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