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Nuclear factor, interleukin 3 regulated
Symbols NFIL3; E4BP4; IL3BP1; NF-IL3A; NFIL3A
External IDs OMIM605327 MGI109495 HomoloGene3928 GeneCards: NFIL3 Gene
RNA expression pattern
PBB GE NFIL3 203574 at tn.png
More reference expression data
Species Human Mouse
Entrez 4783 18030
Ensembl ENSG00000165030 ENSMUSG00000056749
UniProt n/a n/a
RefSeq (mRNA) NM_005384 XM_001000125
RefSeq (protein) NP_005375 XP_001000125
Location (UCSC) Chr 9:
93.21 - 93.23 Mb
Chr 13:
52.98 - 52.99 Mb
PubMed search [1] [2]

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.[1]


Expression of interleukin-3 (IL3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[1][2]


Further reading

  • Cowell IG, Skinner A, Hurst HC (1992). "Transcriptional repression by a novel member of the bZIP family of transcription factors.". Mol. Cell. Biol. 12 (7): 3070–7. PMID 1620116.  
  • Zhang W, Zhang J, Kornuc M, et al. (1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter.". Mol. Cell. Biol. 15 (11): 6055–63. PMID 7565758.  
  • Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.  
  • Cowell IG, Hurst HC (1996). "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1.". Nucleic Acids Res. 24 (18): 3607–13. doi:10.1093/nar/24.18.3607. PMID 8836190.  
  • Ikushima S, Inukai T, Inaba T, et al. (1997). "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2609–14. doi:10.1073/pnas.94.6.2609. PMID 9122243.  
  • Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis.". Hum. Genet. 106 (6): 594–6. doi:10.1007/s004390050030. PMID 10942106.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ozkurt IC, Tetradis S (2003). "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts.". J. Biol. Chem. 278 (29): 26803–9. doi:10.1074/jbc.M212652200. PMID 12743120.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Priceman SJ, Kirzner JD, Nary LJ, et al. (2006). "Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells.". Biochem. Biophys. Res. Commun. 344 (2): 491–9. doi:10.1016/j.bbrc.2006.03.169. PMID 16630563.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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