The Full Wiki

NFIX: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Nuclear factor I/X (CCAAT-binding transcription factor)
Identifiers
Symbols NFIX; NF1A
External IDs OMIM164005 MGI97311 HomoloGene1872 GeneCards: NFIX Gene
RNA expression pattern
PBB GE NFIX 209807 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4784 18032
Ensembl ENSG00000008441 ENSMUSG00000001911
UniProt Q14938 P70257
RefSeq (mRNA) NM_002501 NM_001081981
RefSeq (protein) NP_002492 NP_001075450
Location (UCSC) Chr 19:
12.97 - 13.07 Mb
Chr 8:
87.6 - 87.66 Mb
PubMed search [1] [2]

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.[1][2][3]

Contents

Interactions

NFIX has been shown to interact with SKI protein.[4]

References

  1. ^ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet 91 (6): 535–7. PMID 8340106.  
  2. ^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.  
  3. ^ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4784.  
  4. ^ Tarapore, P; Richmond C, Zheng G, Cohen S B, Kelder B, Kopchick J, Kruse U, Sippel A E, Colmenares C, Stavnezer E (Oct. 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. (ENGLAND) 25 (19): 3895–903. ISSN 0305-1048. PMID 9380514.  

Further reading

  • Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner.". Nucleic Acids Res. 22 (19): 3825–33. doi:10.1093/nar/22.19.3825. PMID 7937100.  
  • Sumner C, Shinohara T, Durham L, et al. (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes.". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200.  
  • Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein.". J. Biol. Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.  
  • Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.  
  • Tarapore P, Richmond C, Zheng G, et al. (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI.". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMID 9380514.  
  • Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo.". J. Biol. Chem. 275 (3): 1645–50. doi:10.1074/jbc.275.3.1645. PMID 10636857.  
  • Nakazato M, Chung HK, Ulianich L, et al. (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression.". Mol. Cell. Biol. 20 (22): 8499–512. doi:10.1128/MCB.20.22.8499-8512.2000. PMID 11046146.  
  • Imagawa M, Sakaue R, Tanabe A, et al. (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A.". FEBS Lett. 484 (2): 118–24. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Gopalan SM, Wilczynska KM, Konik BS, et al. (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes.". J. Biol. Chem. 281 (19): 13126–33. doi:10.1074/jbc.M601194200. PMID 16565071.  
  • Ravichandran V, Sabath BF, Jensen PN, et al. (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.". J. Virol. 80 (21): 10506–13. doi:10.1128/JVI.01355-06. PMID 16928756.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message