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Nuclear transcription factor Y, beta

PDB rendering based on 1n1j.
Available structures
External IDs OMIM189904 MGI97317 HomoloGene38149 GeneCards: NFYB Gene
RNA expression pattern
PBB GE NFYB 218127 at tn.png
PBB GE NFYB 218128 at tn.png
PBB GE NFYB 218129 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4801 18045
Ensembl ENSG00000120837 ENSMUSG00000020248
UniProt P25208 Q8C590
RefSeq (mRNA) NM_006166 NM_010914
RefSeq (protein) NP_006157 NP_035044
Location (UCSC) Chr 12:
103.03 - 103.06 Mb
Chr 10:
82.18 - 82.19 Mb
PubMed search [1] [2]

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.[1][2]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.[3]



NFYB has been shown to interact with CCAAT/enhancer binding protein zeta,[4] CNTN2,[5] TATA binding protein[6] and Myc.[7]


  1. ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4. PMID 1774067.  
  2. ^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci 23 (5): 174–8. PMID 9612081.  
  3. ^ "Entrez Gene: NFYB nuclear transcription factor Y, beta".  
  4. ^ Imbriano, C; Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul. 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. (United States) 276 (28): 26332–9. doi:10.1074/jbc.M101553200. ISSN 0021-9258. PMID 11306579.  
  5. ^ Pise-Masison, C A; Dittmer J, Clemens K E, Brady J N (Mar. 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. (UNITED STATES) 17 (3): 1236–43. ISSN 0270-7306. PMID 9032250.  
  6. ^ Bellorini, M; Lee D K, Dantonel J C, Zemzoumi K, Roeder R G, Tora L, Mantovani R (Jun. 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. ISSN 0305-1048. PMID 9153318.  
  7. ^ Izumi, H; Molander C, Penn L Z, Ishisaki A, Kohno K, Funa K (Apr. 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell. Sci. (England) 114 (Pt 8): 1533–44. ISSN 0021-9533. PMID 11282029.  

Further reading

  • Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex.". Immunobiology 198 (1-3): 249–63. PMID 9442396.  
  • Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y.". Gene 239 (1): 15–27. doi:10.1016/S0378-1119(99)00368-6. PMID 10571030.  
  • Li XY, Mantovani R, Hooft van Huijsduijnen R, et al. (1992). "Evolutionary variation of the CCAAT-binding transcription factor NF-Y.". Nucleic Acids Res. 20 (5): 1087–91. doi:10.1093/nar/20.5.1087. PMID 1549471.  
  • Li XY, Hooft van Huijsduijnen R, Mantovani R, et al. (1992). "Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.". J. Biol. Chem. 267 (13): 8984–90. PMID 1577736.  
  • Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins.". Mol. Cell. Biol. 15 (9): 5092–9. PMID 7651426.  
  • Chang ZF, Liu CJ (1994). "Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts.". J. Biol. Chem. 269 (27): 17893–8. PMID 8027044.  
  • Mantovani R, Li XY, Pessara U, et al. (1994). "Dominant negative analogs of NF-YA.". J. Biol. Chem. 269 (32): 20340–6. PMID 8051128.  
  • Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y.". Mol. Cell. Biol. 17 (3): 1236–43. PMID 9032250.  
  • Bellorini M, Lee DK, Dantonel JC, et al. (1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues.". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMID 9153318.  
  • Currie RA (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).". J. Biol. Chem. 272 (49): 30880–8. doi:10.1074/jbc.272.49.30880. PMID 9388234.  
  • Currie RA (1998). "NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF.". J. Biol. Chem. 273 (3): 1430–4. doi:10.1074/jbc.273.3.1430. PMID 9430679.  
  • Currie RA (1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development.". J. Biol. Chem. 273 (29): 18220–9. doi:10.1074/jbc.273.29.18220. PMID 9660784.  
  • Bemark M, Olsson H, Heinegård D, Leanderson T (1998). "Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription.". J. Biol. Chem. 273 (30): 18881–90. doi:10.1074/jbc.273.30.18881. PMID 9668064.  
  • Faniello MC, Bevilacqua MA, Condorelli G, et al. (1999). "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300.". J. Biol. Chem. 274 (12): 7623–6. doi:10.1074/jbc.274.12.7623. PMID 10075648.  
  • Hake SB, Masternak K, Kammerbauer C, et al. (2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.". Mol. Cell. Biol. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMID 11003667.  
  • Liang F, Schaufele F, Gardner DG (2001). "Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription.". J. Biol. Chem. 276 (2): 1516–22. doi:10.1074/jbc.M006350200. PMID 11022037.  
  • Izumi H, Molander C, Penn LZ, et al. (2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor.". J. Cell. Sci. 114 (Pt 8): 1533–44. PMID 11282029.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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