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Nuclear transcription factor Y, gamma

PDB rendering based on 1n1j.
Available structures
Symbols NFYC; CBF-C; CBFC; DKFZp667G242; FLJ45775; H1TF2A; HAP5; HSM; NF-YC; hCBF-C
External IDs OMIM605344 MGI107901 HomoloGene7440 GeneCards: NFYC Gene
RNA expression pattern
PBB GE NFYC 202215 s at tn.png
PBB GE NFYC 202216 x at tn.png
PBB GE NFYC 211251 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4802 18046
Ensembl ENSG00000066136 ENSMUSG00000032897
UniProt Q13952 Q7TPS7
RefSeq (mRNA) NM_014223 NM_001048168
RefSeq (protein) NP_055038 NP_001041633
Location (UCSC) Chr 1:
40.93 - 41.01 Mb
Chr 4:
120.26 - 120.32 Mb
PubMed search [1] [2]

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.[1][2][3]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.[3]



NFYC has been shown to interact with Myc.[4]


  1. ^ Sinha S, Maity SN, Seldin MF, de Crombrugghe B (Feb 1997). "Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor". Genomics 37 (2): 260–3. doi:10.1006/geno.1996.0555. PMID 8921405.  
  2. ^ Bellorini M, Zemzoumi K, Farina A, Berthelsen J, Piaggio G, Mantovani R (Aug 1997). "Cloning and expression of human NF-YC". Gene 193 (1): 119–25. PMID 9249075.  
  3. ^ a b "Entrez Gene: NFYC nuclear transcription factor Y, gamma".  
  4. ^ Taira, T; Sawai M, Ikeda M, Tamai K, Iguchi-Ariga S M, Ariga H (Aug. 1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". J. Biol. Chem. (UNITED STATES) 274 (34): 24270–9. ISSN 0021-9258. PMID 10446203.  

Further reading

  • Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y.". Gene 239 (1): 15–27. doi:10.1016/S0378-1119(99)00368-6. PMID 10571030.  
  • Martinelli R, Heintz N (1994). "H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulation.". Mol. Cell. Biol. 14 (12): 8322–32. PMID 7969168.  
  • Nakshatri H, Bhat-Nakshatri P, Currie RA (1997). "Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox.". J. Biol. Chem. 271 (46): 28784–91. doi:10.1074/jbc.271.46.28784. PMID 8910521.  
  • Dmitrenko V, Garifulin O, Kavsan V (1997). "Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor.". Gene 197 (1-2): 161–3. doi:10.1016/S0378-1119(97)00255-2. PMID 9332362.  
  • Currie RA (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).". J. Biol. Chem. 272 (49): 30880–8. doi:10.1074/jbc.272.49.30880. PMID 9388234.  
  • Taira T, Sawai M, Ikeda M, et al. (1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y.". J. Biol. Chem. 274 (34): 24270–9. doi:10.1074/jbc.274.34.24270. PMID 10446203.  
  • Yoshida H, Okada T, Haze K, et al. (2001). "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.". Mol. Cell. Biol. 21 (4): 1239–48. doi:10.1128/MCB.21.4.1239-1248.2001. PMID 11158310.  
  • Izumi H, Molander C, Penn LZ, et al. (2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor.". J. Cell. Sci. 114 (Pt 8): 1533–44. PMID 11282029.  
  • Chen F, Ogawa K, Liu X, et al. (2002). "Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit.". Biochem. J. 364 (Pt 2): 571–7. doi:10.1042/BJ20011703. PMID 12023901.  
  • Romier C, Cocchiarella F, Mantovani R, Moras D (2003). "The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.". J. Biol. Chem. 278 (2): 1336–45. doi:10.1074/jbc.M209635200. PMID 12401788.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Salsi V, Caretti G, Wasner M, et al. (2003). "Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.". J. Biol. Chem. 278 (9): 6642–50. doi:10.1074/jbc.M210065200. PMID 12482752.  
  • Hirose T, Sowa Y, Takahashi S, et al. (2003). "p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.". Oncogene 22 (49): 7762–73. doi:10.1038/sj.onc.1207091. PMID 14586402.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro.". Nucleic Acids Res. 32 (12): 3632–41. doi:10.1093/nar/gkh692. PMID 15243141.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wang B, Gao C, Ponder KP (2005). "C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes.". J. Hepatol. 43 (2): 294–302. doi:10.1016/j.jhep.2005.02.029. PMID 15922473.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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