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NHLH1: Wikis


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From Wikipedia, the free encyclopedia

Nescient helix loop helix 1
Symbols NHLH1; HEN1; NSCL; NSCL1
External IDs OMIM162360 MGI98481 HomoloGene4089 GeneCards: NHLH1 Gene
RNA expression pattern
PBB GE NHLH1 214628 at tn.png
More reference expression data
Species Human Mouse
Entrez 4807 18071
Ensembl ENSG00000171786 ENSMUSG00000051251
UniProt Q02575 Q7TQE8
RefSeq (mRNA) NM_005598 NM_010916
RefSeq (protein) NP_005589 NP_035046
Location (UCSC) Chr 1:
158.6 - 158.61 Mb
Chr 1:
173.89 - 173.89 Mb
PubMed search [1] [2]

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.[1]

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM][1]


Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins.". Development 127 (2): 425–35. PMID 10603358.  
  • Begley CG, Lipkowitz S, Göbel V, et al. (1992). "Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 38–42. doi:10.1073/pnas.89.1.38. PMID 1729708.  
  • Brown L, Espinosa R, Le Beau MM, et al. (1992). "HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8492–6. doi:10.1073/pnas.89.18.8492. PMID 1528853.  
  • Lipkowitz S, Göbel V, Varterasian ML, et al. (1992). "A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system.". J. Biol. Chem. 267 (29): 21065–71. PMID 1328219.  


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