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NHLH1: Wikis

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Nescient helix loop helix 1
Identifiers
Symbols NHLH1; HEN1; NSCL; NSCL1
External IDs OMIM162360 MGI98481 HomoloGene4089 GeneCards: NHLH1 Gene
RNA expression pattern
PBB GE NHLH1 214628 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4807 18071
Ensembl ENSG00000171786 ENSMUSG00000051251
UniProt Q02575 Q7TQE8
RefSeq (mRNA) NM_005598 NM_010916
RefSeq (protein) NP_005589 NP_035046
Location (UCSC) Chr 1:
158.6 - 158.61 Mb
Chr 1:
173.89 - 173.89 Mb
PubMed search [1] [2]

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.[1]

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM][1]

References

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins.". Development 127 (2): 425–35. PMID 10603358.  
  • Begley CG, Lipkowitz S, Göbel V, et al. (1992). "Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 38–42. doi:10.1073/pnas.89.1.38. PMID 1729708.  
  • Brown L, Espinosa R, Le Beau MM, et al. (1992). "HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8492–6. doi:10.1073/pnas.89.18.8492. PMID 1528853.  
  • Lipkowitz S, Göbel V, Varterasian ML, et al. (1992). "A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system.". J. Biol. Chem. 267 (29): 21065–71. PMID 1328219.  
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