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NK2 transcription factor related, locus 3 (Drosophila)
Symbols NKX2-3; NKX2.3; NKX2C
External IDs OMIM606727 MGI97348 HomoloGene17061 GeneCards: NKX2-3 Gene
Species Human Mouse
Entrez 159296 18089
Ensembl ENSG00000119919 ENSMUSG00000044220
UniProt Q8TAU0 P97334
RefSeq (mRNA) NM_145285 NM_008699
RefSeq (protein) NP_660328 NP_032725
Location (UCSC) Chr 10:
101.28 - 101.29 Mb
Chr 19:
43.67 - 43.67 Mb
PubMed search [1] [2]

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.[1][2][3]

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions. See Harvey (1996) for a review of the structure, regulation, function, and evolution of NK2 homeobox genes with an emphasis on their roles in heart development.[supplied by OMIM][3]


  1. ^ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron 8 (2): 241-55. PMID 1346742.  
  2. ^ Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn 209 (1): 29-35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.  
  3. ^ a b "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".  

Further reading

  • Harvey RP (1996). "NK-2 homeobox genes and heart development.". Dev. Biol. 178 (2): 203–16. doi:10.1006/dbio.1996.0212. PMID 8812123.  
  • Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen.". Development 126 (10): 2215–25. PMID 10207146.  
  • Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues.". J. Biol. Chem. 276 (37): 34637–50. doi:10.1074/jbc.M105826200. PMID 11457859.  
  • Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis.". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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