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NK3 transcription factor related, locus 1 (Drosophila)
Symbols NKX3-1; BAPX2; NKX3; NKX3.1; NKX3A
External IDs OMIM602041 MGI97352 HomoloGene4494 GeneCards: NKX3-1 Gene
RNA expression pattern
PBB GE NKX3-1 209706 at tn.png
PBB GE NKX3-1 211497 x at tn.png
PBB GE NKX3-1 211498 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4824 18095
Ensembl ENSG00000167034 ENSMUSG00000022061
UniProt Q99801 Q3UVH8
RefSeq (mRNA) NM_006167 NM_010921
RefSeq (protein) NP_006158 NP_035051
Location (UCSC) Chr 8:
23.59 - 23.6 Mb
Chr 14:
68.14 - 68.15 Mb
PubMed search [1] [2]

Homeobox protein Nkx-3.1 is a protein that in humans is encoded by the NKX3-1 gene.[1]

The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM][2]



NKX3-1 has been shown to interact with SPDEF.[3]


  1. ^ He WW, Sciavolino PJ, Wing J, Augustus M, Hudson P, Meissner PS, Curtis RT, Shell BK, Bostwick DG, Tindall DJ, Gelmann EP, Abate-Shen C, Carter KC (Sep 1997). "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer". Genomics 43 (1): 69–77. doi:10.1006/geno.1997.4715. PMID 9226374.  
  2. ^ "Entrez Gene: NKX3-1 NK3 transcription factor related, locus 1 (Drosophila)".  
  3. ^ Chen, Hui; Nandi Asit K, Li Xiang, Bieberich Charles J (Jan. 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. (United States) 62 (2): 338–40. ISSN 0008-5472. PMID 11809674.  

Further reading

  • Shen MM, Abate-Shen C (2004). "Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.". Dev. Dyn. 228 (4): 767–78. doi:10.1002/dvdy.10397. PMID 14648854.  
  • Abdulkadir SA (2006). "Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1.". Ann. N. Y. Acad. Sci. 1059: 33–40. doi:10.1196/annals.1339.018. PMID 16382041.  
  • Voeller HJ, Augustus M, Madike V, et al. (1997). "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.". Cancer Res. 57 (20): 4455–9. PMID 9377551.  
  • Prescott JL, Blok L, Tindall DJ (1998). "Isolation and androgen regulation of the human homeobox cDNA, NKX3.1.". Prostate 35 (1): 71–80. doi:10.1002/(SICI)1097-0045(19980401)35:1<71::AID-PROS10>3.0.CO;2-H. PMID 9537602.  
  • Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.". J. Biol. Chem. 274 (47): 33194–7. doi:10.1074/jbc.274.47.33194. PMID 10559189.  
  • Carson JA, Fillmore RA, Schwartz RJ, Zimmer WE (2001). "The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor.". J. Biol. Chem. 275 (50): 39061–72. doi:10.1074/jbc.M006532200. PMID 10993896.  
  • Bowen C, Bubendorf L, Voeller HJ, et al. (2000). "Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.". Cancer Res. 60 (21): 6111–5. PMID 11085535.  
  • Korkmaz KS, Korkmaz CG, Ragnhildstveit E, et al. (2001). "Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens.". Gene 260 (1-2): 25–36. doi:10.1016/S0378-1119(00)00453-4. PMID 11137288.  
  • Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.". Cancer Res. 62 (2): 338–40. PMID 11809674.  
  • Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia.". Gene Expr. 10 (5-6): 201–11. PMID 12450213.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gelmann EP, Bowen C, Bubendorf L (2003). "Expression of NKX3.1 in normal and malignant tissues.". Prostate 55 (2): 111–7. doi:10.1002/pros.10210. PMID 12661036.  
  • Skotheim RI, Korkmaz KS, Klokk TI, et al. (2004). "NKX3.1 expression is lost in testicular germ cell tumors.". Am. J. Pathol. 163 (6): 2149–54. PMID 14633588.  
  • Korkmaz CG, Korkmaz KS, Manola J, et al. (2004). "Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis.". J. Urol. 172 (3): 1134–9. doi:10.1097/01.ju.0000136526.78535.b8. PMID 15311057.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Chen H, Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673.  
  • Lind GE, Skotheim RI, Fraga MF, et al. (2005). "The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation.". Mol. Cancer 4 (1): 8. doi:10.1186/1476-4598-4-8. PMID 15691383.  
  • Asatiani E, Huang WX, Wang A, et al. (2005). "Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer.". Cancer Res. 65 (4): 1164–73. doi:10.1158/0008-5472.CAN-04-2688. PMID 15734999.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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