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NK3 homeobox 2
Symbol NKX3-2
Alt. symbols BAPX1
Entrez 579
HUGO 951
OMIM 602183
RefSeq NM_001189
UniProt P78367
Other data
Locus Chr. 4 p16.3

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.[1]


NKX3-2 plays a role in the development of the skeleton.[2] Nkx3-2 in mice also regulates patterning in the middle ear.[3]


  1. ^ Yoshiura KI, Murray JC (October 1997). "Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia". Genomics 45 (2): 425–8. doi:10.1006/geno.1997.4926. PMID 9344671.  
  2. ^ Lettice L, Hecksher-Sørensen J, Hill R (2001). "The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton". J. Anat. 199 (Pt 1-2): 181–7. doi:10.1111/j.1469-7580.2008.00944.x. PMID 11523821.  
  3. ^ Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE (2004). "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution". Development 131 (6): 1235–1245. doi:10.1242/dev.01017. PMID 14973294.  

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