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NNC 38-1049: Wikis

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NNC 38-1049
NNC38-1049 structure.png
IUPAC name
Identifiers
CAS number 757183-18-9
SMILES
Properties
Molecular formula C19H25ClN2O2
Molar mass 348.866 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

NNC 38-1049 is a histamine antagonist selective for the H3 subtype. It has anorectic effects in animal studies and is being researched as a potential treatment for obesity.[1][2]

References

  1. ^ Malmlöf K, Zaragoza F, Golozoubova V, et al. (December 2005). "Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight". Int J Obes (Lond) 29 (12): 1402–12. doi:10.1038/sj.ijo.0803036. PMID 16151415. http://dx.doi.org/10.1038/sj.ijo.0803036.  
  2. ^ Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Obesity (Silver Spring). 2006 Dec;14(12):2154-62. PMID 17189541
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