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Neuronal PAS domain protein 2
Symbols NPAS2; FLJ23138; MGC71151; MOP4; PASD4
External IDs OMIM603347 MGI109232 HomoloGene1887 GeneCards: NPAS2 Gene
RNA expression pattern
PBB GE NPAS2 39548 at tn.png
PBB GE NPAS2 205459 s at tn.png
PBB GE NPAS2 205460 at tn.png
More reference expression data
Species Human Mouse
Entrez 4862 18143
Ensembl ENSG00000170485 ENSMUSG00000026077
UniProt Q99743 Q32ME6
RefSeq (mRNA) NM_002518 NM_008719
RefSeq (protein) NP_002509 NP_032745
Location (UCSC) Chr 2:
100.8 - 100.98 Mb
Chr 1:
39.14 - 39.31 Mb
PubMed search [1] [2]

Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.[1][2]

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.[3]



NPAS2 has been shown to interact with Retinoic acid receptor alpha,[4] EP300,[5] ARNTL[4][6] and Retinoid X receptor alpha.[4]


  1. ^ Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (Mar 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc Natl Acad Sci U S A 94 (2): 713–8. PMID 9012850.  
  2. ^ Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (May 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J Biol Chem 272 (13): 8581–93. PMID 9079689.  
  3. ^ "Entrez Gene: NPAS2 neuronal PAS domain protein 2".  
  4. ^ a b c McNamara, P; Seo S B, Rudic R D, Sehgal A, Chakravarti D, FitzGerald G A (Jun. 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell (United States) 105 (7): 877–89. ISSN 0092-8674. PMID 11439184.  
  5. ^ Curtis, Anne M; Seo Sang-beom, Westgate Elizabeth J, Rudic Radu Daniel, Smyth Emer M, Chakravarti Debabrata, FitzGerald Garret A, McNamara Peter (Feb. 2004). "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock". J. Biol. Chem. (United States) 279 (8): 7091–7. doi:10.1074/jbc.M311973200. ISSN 0021-9258. PMID 14645221.  
  6. ^ Hogenesch, J B; Gu Y Z, Jain S, Bradfield C A (May. 1998). "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (10): 5474–9. ISSN 0027-8424. PMID 9576906.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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