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natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
External IDs OMIM108961 MGI97372 HomoloGene2970 GeneCards: NPR2 Gene
Species Human Mouse
Entrez 4882 230103
Ensembl ENSG00000159899 ENSMUSG00000028469
UniProt P20594 Q6VVW5
RefSeq (mRNA) NM_003995 NM_173788
RefSeq (protein) NP_003986 NP_776149
Location (UCSC) Chr 9:
35.78 - 35.8 Mb
Chr 4:
43.64 - 43.66 Mb
PubMed search [1] [2]

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is a protein that in humans is encoded by the NPR2 gene.[1]



Further reading

  • Fox AA, Collard CD, Shernan SK, et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.". Anesthesiology 110 (4): 738-47. PMID 19326473.  
  • Potthast R, Abbey-Hosch SE, Antos LK, et al. (2004). "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B.". J. Biol. Chem. 279 (47): 48513-9. doi:10.1074/jbc.M408247200. PMID 15371450.  
  • Liew D, Schneider H, D'Agostino J, et al. (2004). "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al.". Diabetes Care 27 (3): 848; author reply 848-9. PMID 14988324.  
  • Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (2005). "ATP-independent activation of natriuretic peptide receptors.". J. Biol. Chem. 280 (29): 26928-32. doi:10.1074/jbc.M505648200. PMID 15911610.  
  • Poreba R, Poczatek K, Gać P, et al. (2009). "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension.". Pol. Arch. Med. Wewn. 119 (4): 219-24. PMID 19413180.  
  • Koller KJ, Goeddel DV (1992). "Molecular biology of the natriuretic peptides and their receptors.". Circulation 86 (4): 1081-8. PMID 1327579.  
  • Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.". Mol. Pharmacol. 67 (1): 174-83. doi:10.1124/mol.104.002436. PMID 15459247.  
  • Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (2007). "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy.". J. Mol. Med. 85 (8): 797-810. doi:10.1007/s00109-007-0183-4. PMID 17429599.  
  • Rahmutula D, Cui J, Chen S, Gardner DG (2004). "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1.". Hypertension 44 (3): 283-8. doi:10.1161/01.HYP.0000136908.60317.92. PMID 15262909.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.  
  • Hume AN, Buttgereit J, Al-Awadhi AM, et al. (2009). "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.". Hum. Mol. Genet. 18 (2): 267-77. doi:10.1093/hmg/ddn354. PMID 18945719.  
  • Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor.". Peptides 26 (6): 1024-34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070.  
  • Tsuji T, Kunieda T (2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.". J. Biol. Chem. 280 (14): 14288-92. doi:10.1074/jbc.C500024200. PMID 15722353.  
  • Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.". J. Biol. Chem. 284 (29): 19196-202. doi:10.1074/jbc.M109.010777. PMID 19458086.  
  • Nozohoor S, Nilsson J, Lührs C, et al. (2009). "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement.". J. Cardiothorac. Vasc. Anesth. 23 (2): 161-5. doi:10.1053/j.jvca.2008.11.006. PMID 19167912.  
  • Hachiya R, Ohashi Y, Kamei Y, et al. (2007). "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development.". J. Clin. Endocrinol. Metab. 92 (10): 4009-14. doi:10.1210/jc.2007-1101. PMID 17652215.  
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808-16. doi:10.1002/ajmg.b.30902. PMID 19086053.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Bartels CF, Bükülmez H, Padayatti P, et al. (2004). "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux.". Am. J. Hum. Genet. 75 (1): 27-34. doi:10.1086/422013. PMID 15146390.  
  • van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors.". J. Mol. Biol. 311 (5): 923-37. doi:10.1006/jmbi.2001.4922. PMID 11556325.  

See also

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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