The Full Wiki

More info on Nabumetone

Nabumetone: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Nabumetone
Systematic (IUPAC) name
4-(6-methoxy-2-naphthyl)-2-butanone
Identifiers
CAS number 42924-53-8
ATC code M01AX01
PubChem 4409
DrugBank APRD01128
Chemical data
Formula C 15H16O2  
Mol. mass 228.29 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding > 99% (active metabolite)
Metabolism Hepatic, to active metabolite 6-methoxy-2-naphthylacetic acid; 6-MNA
Half life 23 hours (active metabolite)
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status POM
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Nabumetone is a non-steroidal anti-inflammatory drug[1] (NSAID) of the arylalkanoic acid family (which includes diclofenac). Nabumetone has been developed by Beecham. It is available under numerous brand names, such as Relafen, Relifex and Gambaran.

It is used to treat pain or inflammation caused by arthritis. Nabumetone works by reducing the effects of hormones that cause pain and inflammation.

It has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAIDs.

References

  1. ^ Gonzalo-Garijo MA, Cordobés-Duran C, Lamilla-Yerga AM, Moreno-Gastón I (2007). "Severe immediate reaction to nabumetone". Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 17 (4): 274–6. PMID 17694703.  







Got something to say? Make a comment.
Your name
Your email address
Message