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Naftifine
Systematic (IUPAC) name
(2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
Identifiers
CAS number 65472-88-0
ATC code D01AE22
PubChem 47641
DrugBank DB00735
Chemical data
Formula C21H21N 
Mol. mass 287.398 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status
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Naftifine (brand name Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.[1][2] The half life is approximate 2-3 days.[2][3] The metabolites are excreted in the urine and feces.[3][4]

References

  1. ^ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
  2. ^ a b Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at http://www.thomsonhc.com/hcs/librarian/ND_T/HCS/ND_PR/Main/CS/7ED8A6/DUPLICATIONSHIELDSYNC/89971B/ND_PG/PRIH/ND_B/HCS/SBK/2/ND_P/Main/PFActionId/hcs.common.RetrieveDocumentCommon/DocId/390170/ContentSetId/100/SearchTerm/naftifine/SearchOption/BeginWith#secN10184, February 18, 2010.
  3. ^ a b UptoDate Inc: Naftifine: Drug information. Accessed at http://www.utdol.com/online/content/topic.do?topicKey=drug_l_z/174337&selectedTitle=1~8&source=search_result#F199214, February 18, 2010.
  4. ^ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.
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