The Full Wiki

Nairovirus: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Nairovirus
Virus classification
Group: Group V ((-)ssRNA)
Family: Bunyaviridae
Genus: Nairovirus
Species

Crimean-Congo hemorrhagic fever virus (CCHFV)
Dera Ghazi Khan virus (DGKV)
Dugbe virus (DUGV)
Hughes virus (HUGV)
Qalyub virus (QYBV)
Sakhalin virus (SAKV)
Thiafora virus (TFAV)

Nairovirus is a genus in the family Bunyaviridae that include viruses with circular, negative-sense single stranded RNA. It got its name from the Nairobi sheep disease that affects the gastrointestinal tracts of sheep and goats. Viruses in this genus are tick-borne viruses that can have human or animal hosts.[1] There are seven species in this genus which include: Crimean-Congo hemorrhagic fever virus (CCHFV); Dugbe virus (DUGV); Qalyub virus (QYBV); Sakhalin virus (SAKV); Dera Ghazi Khan virus (DGKV); Thiafora virus (TFAV); and Hughes virus (HUGV).[1][2]

Contents

Genome

Nairovirus genomes are monomeric, segmented, circular, negative sense, single-stranded RNA. The complete genome is about 17,100-22,800 nucleotides long and is segmented into three segments: large, medium, and small.[1] The large segment is about 11000-14400 nucleotides long (6.8–12 kb) and it encodes for the nucleocapsid protein.[3][4] The medium segment is about 4,400-6,300 nucleotides long (3.2-4.9kb) and it encodes for glycoproteins G¬n and Gc.[3][4] The small segment is about 1,700-2,100 nucleotides long (1-3kb) and it encodes the viral polymerase.[1][3][4]

The genome has terminally redundant sequences with the sequences being repeated at both ends. The terminal nucleotides are base-paired forming non-covalently closed, circular RNA.[3] Both the 5’ and 3’ end have conserved regions of 9 nucleotides in length. The sequences are 5’end UCUCAAAGA and 3’end AGAGUUUCU.[3]

Virion

The virions for viruses in this genus have a spherical shape.[4] They range in size from about 80-120 nm in diameter with 50% of their weight attributed to proteins and 20-30% of their weight attributed to lipids.[3] The virions have 3 non-segmented, circular, symmetric nucleocapsids. The ribonucleocapsid is filamentous and has a length of about 200-300 nm and a width of about 2-2.5 nm.[3]

These nucleocapsids are surrounded by a single envelope that has projections made of glycoproteins protruding from its surface. These projections evenly cover the surface of the virion and are about 5-10 nm long.[3] They aid in attachment to the host receptor in replication.

Replication

These viruses are not dependent on a helper virus. They attach to the host receptors by their Gn-Gc glycoprotein dimer.[4] The virus is then endocytosed into the host cell via a vesicle. The ribonucleocapsid segments are released into the cytoplasm commencing transcription.[4] Transcription and replication occur in the cell and the newly synthesized virions are released by budding.

Transmission & Distribution

This virus infects many different vertebrate hosts and is transmitted via insects such as ticks and flies.[3]

There are no geographical localizations of this virus. It is widespread. However, the Crimean-Congo hemorrhagic fever virus is localized to Africa, Asia and Europe.[4]

Notes and references

  1. ^ a b c d Crabtree, Mary B., Rosemary Sang, and Barry R. Miller. "Kupe Virus, a New Virus in the Family Bunyaviridae, Genus Nairovirus, Kenya." Emerging Infectious Diseases 15 (2009): 147-54.
  2. ^ Clerx, John PM, Jordi Casals, and David HL Bishop. "Structural Characteristics of Nairoviruses (Genus Nairovirus, Bunyaviridae)." Journal of General Virology 55 (1981): 165-78.
  3. ^ a b c d e f g h i Büchen-Osmond, Cornelia. "00.011.0.03. Nairovirus." ICTVdb Virus Descriptions. 25 Apr. 2006. International Committee on Taxonomy of Viruses. 17 Apr. 2009 <http://phene.cpmc.columbia.edu/ICTVdB/00.011.0.03.htm>.
  4. ^ a b c d e f g "Nairovirus." Nairovirus. Viral Zone. <http://www.expasy.ch/viralzone/all_by_species/251.html>.

External links

Advertisements

Wikispecies

Up to date as of January 23, 2010

From Wikispecies

Taxonavigation

Main Page
Regnum: Virus
Phylum: not divided
Classis: not divided
Ordo: Unassigned
Familia: Bunyaviridae
Genus: Nairovirus
Species: Crimean-Congo hemorrhagic fever virus  -   Dera Ghazi Khan virus  -   Dugbe virus  -   Hughes virus  -   Qalyub virus  -   Sakhalin virus  -   Thiafora virus

References

Catalogue of Life: 2009 Annual Checklist [1]


Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message