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Nalfurafine: Wikis

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Nalfurafine
Systematic (IUPAC) name
(2E)-N-[(5α,6β)-17-(cyclopropylmethyl)- 3,14-dihydroxy- 4,5-epoxymorphinan- 6-yl]- 3-(3-furyl)- N-methylacrylamide
Identifiers
CAS number 152658-17-8
ATC code V03AX02
PubChem 6445230
Chemical data
Formula C 28H32N2O5  
Mol. mass 476.564 g/mol
Synonyms TRK-820
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes intravenous

Nalfurafine (INN and USAN;[1] also known as AC-820, TRK-820; trade name Remitch) is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in people undergoing hemodialysis.[2]

As of January 2010, it is also being investigated for the treatment of pruritus in patients with chronic liver disease.[3]

References

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