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sodium channel, voltage-gated, type XI, alpha subunit
Available structures
1byy
Identifiers
Symbols SCN11A; NaN; SCN12A
External IDs OMIM604385 MGI1345149 HomoloGene8041 IUPHAR: Nav1.9 GeneCards: SCN11A Gene
Orthologs
Species Human Mouse
Entrez 11280 24046
Ensembl ENSG00000168356 ENSMUSG00000034115
UniProt Q9UI33 Q810E1
RefSeq (mRNA) NM_014139 NM_011887
RefSeq (protein) NP_054858 NP_036017
Location (UCSC) Chr 3:
38.86 - 38.97 Mb
Chr 9:
119.66 - 119.73 Mb
PubMed search [1] [2]

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel protein which in humans is encoded by the SCN11A gene.[1][2]

References

  1. ^ Dib-Hajj S, Black JA, Cummins TR, Waxman SG (2002). "NaN/Nav1.9: a sodium channel with unique properties". Trends Neurosci. 25 (5): 253–9. doi:10.1016/S0166-2236(02)02150-1. PMID 11972962.  
  2. ^ Dib-Hajj SD, Tyrrell L, Waxman SG (2002). "Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution". Mol. Neurobiol. 26 (2-3): 235–50. doi:10.1385/MN:26:2-3:235. PMID 12428758.  

Further reading

  • Delmas P, Coste B (2003). "Na+ channel Nav1.9: in search of a gating mechanism.". Trends Neurosci. 26 (2): 55-7. PMID 12536125.  
  • Blum R, Kafitz KW, Konnerth A (2002). "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9.". Nature 419 (6908): 687-93. doi:10.1038/nature01085. PMID 12384689.  
  • Raymond CK, Castle J, Garrett-Engele P, et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.". J. Biol. Chem. 279 (44): 46234-41. doi:10.1074/jbc.M406387200. PMID 15302875.  
  • Dib-Hajj SD, Tyrrell L, Escayg A, et al. (1999). "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN.". Genomics 59 (3): 309-18. doi:10.1006/geno.1999.5890. PMID 10444332.  
  • Dib-Hajj SD, Tyrrell L, Cummins TR, et al. (1999). "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons.". FEBS Lett. 462 (1-2): 117-20. PMID 10580103.  
  • Jeong SY, Goto J, Hashida H, et al. (2000). "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A.". Biochem. Biophys. Res. Commun. 267 (1): 262-70. doi:10.1006/bbrc.1999.1916. PMID 10623608.  
  • Goldin AL, Barchi RL, Caldwell JH, et al. (2000). "Nomenclature of voltage-gated sodium channels.". Neuron 28 (2): 365-8. PMID 11144347.  
  • Catterall WA, Goldin AL, Waxman SG (2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.". Pharmacol. Rev. 57 (4): 397-409. doi:10.1124/pr.57.4.4. PMID 16382098.  

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