The Full Wiki

More info on Nav1.9

Nav1.9: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

sodium channel, voltage-gated, type XI, alpha subunit
Available structures
Symbols SCN11A; NaN; SCN12A
External IDs OMIM604385 MGI1345149 HomoloGene8041 IUPHAR: Nav1.9 GeneCards: SCN11A Gene
Species Human Mouse
Entrez 11280 24046
Ensembl ENSG00000168356 ENSMUSG00000034115
UniProt Q9UI33 Q810E1
RefSeq (mRNA) NM_014139 NM_011887
RefSeq (protein) NP_054858 NP_036017
Location (UCSC) Chr 3:
38.86 - 38.97 Mb
Chr 9:
119.66 - 119.73 Mb
PubMed search [1] [2]

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel protein which in humans is encoded by the SCN11A gene.[1][2]


  1. ^ Dib-Hajj S, Black JA, Cummins TR, Waxman SG (2002). "NaN/Nav1.9: a sodium channel with unique properties". Trends Neurosci. 25 (5): 253–9. doi:10.1016/S0166-2236(02)02150-1. PMID 11972962.  
  2. ^ Dib-Hajj SD, Tyrrell L, Waxman SG (2002). "Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution". Mol. Neurobiol. 26 (2-3): 235–50. doi:10.1385/MN:26:2-3:235. PMID 12428758.  

Further reading

  • Delmas P, Coste B (2003). "Na+ channel Nav1.9: in search of a gating mechanism.". Trends Neurosci. 26 (2): 55-7. PMID 12536125.  
  • Blum R, Kafitz KW, Konnerth A (2002). "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9.". Nature 419 (6908): 687-93. doi:10.1038/nature01085. PMID 12384689.  
  • Raymond CK, Castle J, Garrett-Engele P, et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.". J. Biol. Chem. 279 (44): 46234-41. doi:10.1074/jbc.M406387200. PMID 15302875.  
  • Dib-Hajj SD, Tyrrell L, Escayg A, et al. (1999). "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN.". Genomics 59 (3): 309-18. doi:10.1006/geno.1999.5890. PMID 10444332.  
  • Dib-Hajj SD, Tyrrell L, Cummins TR, et al. (1999). "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons.". FEBS Lett. 462 (1-2): 117-20. PMID 10580103.  
  • Jeong SY, Goto J, Hashida H, et al. (2000). "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A.". Biochem. Biophys. Res. Commun. 267 (1): 262-70. doi:10.1006/bbrc.1999.1916. PMID 10623608.  
  • Goldin AL, Barchi RL, Caldwell JH, et al. (2000). "Nomenclature of voltage-gated sodium channels.". Neuron 28 (2): 365-8. PMID 11144347.  
  • Catterall WA, Goldin AL, Waxman SG (2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.". Pharmacol. Rev. 57 (4): 397-409. doi:10.1124/pr.57.4.4. PMID 16382098.  

External links



Got something to say? Make a comment.
Your name
Your email address