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Nedocromil: Wikis


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Systematic (IUPAC) name
4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
CAS number 69049-73-6
ATC code R01AC07 R03BC03, S01GX04
PubChem 50294
DrugBank APRD01137
Chemical data
Formula C 19H17NO7  
Mol. mass 371.341 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 89%
Metabolism not metabolized
Half life ~3.3 hours
Excretion excreted unchanged
Therapeutic considerations
Pregnancy cat.  ?
Legal status POM (UK) -only (US)
Routes Inhalation and eye drops
 Yes check.svgY(what is this?)  (verify)

Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.[1]

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.[2]




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