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Neurocan: Wikis


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From Wikipedia, the free encyclopedia

Symbols NCAN; CSPG3; FLJ44681
External IDs OMIM600826 MGI104694 HomoloGene3229 GeneCards: NCAN Gene
Species Human Mouse
Entrez 1463 13004
Ensembl ENSG00000130287 n/a
UniProt O14594 n/a
RefSeq (mRNA) NM_004386 XM_987456
RefSeq (protein) NP_004377 XP_992550
Location (UCSC) Chr 19:
19.18 - 19.22 Mb
PubMed search [1] [2]

Neurocan core protein is a protein that in humans is encoded by the NCAN gene.[1][2]

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM ][2]


  1. ^ Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem 267 (27): 19536-47. PMID 1326557.  
  2. ^ a b "Entrez Gene: NCAN neurocan".  

Further reading

  • Rauch U, Grimpe B, Kulbe G, et al. (1996). "Structure and chromosomal localization of the mouse neurocan gene.". Genomics 28 (3): 405–10. PMID 7490074.  
  • Friedlander DR, Milev P, Karthikeyan L, et al. (1994). "The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth.". J. Cell Biol. 125 (3): 669–80. PMID 7513709.  
  • Milev P, Maurel P, Häring M, et al. (1996). "TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM.". J. Biol. Chem. 271 (26): 15716–23. PMID 8663515.  
  • Retzler C, Göhring W, Rauch U (1996). "Analysis of neurocan structures interacting with the neural cell adhesion molecule N-CAM.". J. Biol. Chem. 271 (44): 27304–10. PMID 8910306.  
  • Rauch U, Clement A, Retzler C, et al. (1997). "Mapping of a defined neurocan binding site to distinct domains of tenascin-C.". J. Biol. Chem. 272 (43): 26905–12. PMID 9341124.  
  • Milev P, Chiba A, Häring M, et al. (1998). "High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule.". J. Biol. Chem. 273 (12): 6998–7005. PMID 9507007.  
  • Prange CK, Pennacchio LA, Lieuallen K, et al. (1998). "Characterization of the human neurocan gene, CSPG3.". Gene 221 (2): 199–205. PMID 9795216.  
  • Oleszewski M, Gutwein P, von der Lieth W, et al. (2000). "Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding.". J. Biol. Chem. 275 (44): 34478–85. doi:10.1074/jbc.M004147200. PMID 10934197.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  


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