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tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Identifiers
Symbol TAC1
Alt. symbols TAC2, NKNA
Entrez 6863
HUGO 11517
OMIM 162320
RefSeq NM_013998
UniProt P20366
Other data
Locus Chr. 7 q21-q22
Neurokinin A
Neurokinin A.png
Identifiers
CAS number 86933-74-6
PubChem 55582
MeSH Neurokinin+A
Properties
Molecular formula C50H80N14O14S
Molar mass 1133.32
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Neurokinin A (formerly known as substance K) is a member of the tachykinin family of neuropeptide neurotransmitters. It is produced from the same preprotachykinin A gene as the neuropeptide substance P. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the rat colon and bronchoconstriction through the non-adrenergic non-cholinergic nervous system (a branch of the vagal system). Neuropeptide K (which has also been called neurokinin K[1])and neuropeptide gamma are N-terminally longer versions of neurokinin A, produced from the same splice forms of the same gene, which appear to be final peptide products in some tissues.[2]

References

  1. ^ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487
  2. ^ Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945
  • Maggi C, Patacchini R, Rovero P, Giachetti A (1993). "Tachykinin receptors and tachykinin receptor antagonists". J Auton Pharmacol 13 (1): 23–93. doi:10.1111/j.1474-8673.1993.tb00396.x. PMID 8382703.  
  • Regoli D, Boudon A, Fauchére J (1994). "Receptors and antagonists for substance P and related peptides". Pharmacol Rev 46 (4): 551–99. PMID 7534932.  
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tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Identifiers
Symbol TAC1
Alt. symbols TAC2, NKNA
Entrez 6863
HUGO 11517
OMIM 162320
RefSeq NM_013998
UniProt P20366
Other data
Locus Chr. 7 q21-q22
Neurokinin A
File:Neurokinin
Identifiers
CAS number 86933-74-6
PubChem 55582
MeSH Neurokinin+A
Properties
Molecular formula C50H80N14O14S
Molar mass 1133.32
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Neurokinin A (formerly known as substance K) is a member of the tachykinin family of neuropeptide neurotransmitters. It is produced from the same preprotachykinin A gene as the neuropeptide substance P. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the rat colon and bronchoconstriction through the non-adrenergic non-cholinergic nervous system (a branch of the vagal system). Neuropeptide K (which has also been called neurokinin K[1]) and neuropeptide gamma are N-terminally longer versions of neurokinin A, produced from the same splice forms of the same gene, which appear to be final peptide products in some tissues.[2]

References

  1. ^ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487
  2. ^ Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945
  • Maggi C, Patacchini R, Rovero P, Giachetti A (1993). [Expression error: Unexpected < operator "Tachykinin receptors and tachykinin receptor antagonists"]. J Auton Pharmacol 13 (1): 23–93. doi:10.1111/j.1474-8673.1993.tb00396.x. PMID 8382703. 
  • Regoli D, Boudon A, Fauchére J (1994). [Expression error: Unexpected < operator "Receptors and antagonists for substance P and related peptides"]. Pharmacol Rev 46 (4): 551–99. PMID 7534932. 

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